Results 101 to 110 of about 6,314,192 (308)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Standard of care and direct medical costs of the treatment of chronic lymphocytic leukemia among the adult population in Ukraine, Russia, and Kazakhstan: data from the LEUKOSPECT study

Cancer Management and Research, 2017
Averyan Vasylyev,1 Valentina Molostvova,2 Boris A Rebrov,3 Janina Makarova,4 Andrey Zaritskey,5 Vadim Ptushkin,6 Raigul Ramazanova,7 Yuriy Popovych,8 Orest Tsyapka,9 Evgeny Pashanov10 1CIS Medical, GlaxoSmithKline, Kiev, Ukraine; 2Regional Clinical ...
Vasylyev A, Molostvova V, Rebrov BA, Makarova J, Zaritskey A, Ptushkin V, Ramazanova R, Popovych Y, Tsyapka O, Pashanov E   +9 more
doaj  

Spatial competition between health care providers: effects of standardization [PDF]

In the international health care literature there is a broad discussion on impacts of competition in health care markets. But aspects of standardization in regional health care markets with no price competition received comparatively little attention. We
Kuchinke, Björn A., Wiese, Nadine, Zerth, Jürgen   +2 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

PromarkerD Versus Standard of Care Biochemical Measures for Assessing Future Renal Function Decline in Type 2 Diabetes

Diagnostics
Background/Objectives: The current standard of care for assessing chronic kidney disease complicating diabetes (DKD) includes measurement of estimated glomerular filtration rate (eGFR) and urinary albumin:creatinine ratio (uACR) but both tests have ...
Kirsten E. Peters, Isabella A. Joubert, Scott D. Bringans, Wendy A. Davis, Richard J. Lipscombe, Timothy M. E. Davis   +5 more
doaj   +1 more source

Predictors of Extra Care Among Magnesium Sulphate treated eclamptic patients at Muhimbili National Hospital, Tanzania. [PDF]

, 2011
\ud The inclusion of Magnesium Sulphate (MgSO4) as a gold standard in the treatment of eclampsia has substantially reduced incidences of repeated fits, eclamptic morbidity and deaths.
Muganyizi, Projestine S, Shagdara, Mohammed S   +1 more
core   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Gold Standard Care of Chronic Scrotal Pain

Research and Reports in Urology, 2021
Stefan Artell Malaguti,1 Lars Lund1,2 1Department of Urology, Odense University Hospital, Odense, Denmark; 2Department of Clinical Research, University of Southern Denmark, Odense, DenmarkCorrespondence: Lars LundDepartment of Urology, Odense University ...
Malaguti SA, Lund L
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Case Report: Dostarlimab for treatment of aggressive cutaneous squamous cell carcinoma

Frontiers in Medicine
Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy with the aggressive cSCC subtype being especially worrisome due to its higher metastatic and mortality rate.
Sophia Gandarillas, Horace Tang, Bahar Dasgeb   +2 more
doaj   +1 more source