Results 171 to 180 of about 171,216,168 (330)

Systemic lupus erythematosus: Auditing standard of care in Qatar. [PDF]

Qatar Med J
Safieh M, Al-Allaf AW.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Improving clinician knowledge, comfort, and adherence to standard of care for suspected child abuse. [PDF]

BMC Pediatr
DiGangi MJ, Stewart S, Taragano E, Cheng J, Barton L, Negriff S.   +5 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Defining the Standard of Care in Fournier's Gangrene-An Umbrella Review. [PDF]

Eur Urol Open Sci
Müssgens C, Wimmer L, Fankhauser CD, Schneidewind L, Aschwanden FJ.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Editorial: New insights into caring for pediatric patients with cystic fibrosis

Frontiers in Pediatrics, 2023
Stephanie Bui, Stephanie Bui, Laurence Delhaes, Laurence Delhaes, Gael Dournes, Gael Dournes, Philippe Reix, Philippe Reix, Michael John Fayon, Michael John Fayon   +9 more
doaj   +1 more source

Network meta-analysis of triple immunosuppressive therapies and standard of care for induction of remission of active lupus nephritis. [PDF]

Lupus
Contreras G, Mechery V, Kota S, Del Castillo Rix D, Bandes M, Dejman A, Zuo Y, Duque JC, Munoz Mendoza J.   +8 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Accommodation with anticancer drug shortage: A Lebanese harmful solution

Frontiers in Oncology, 2023
Clarisse Kattan, Joseph Kattan
doaj   +1 more source