Results 181 to 190 of about 1,071,315 (219)

Living in the United States Stroke Belt and cognitive change in the Women's Health Study: a cohort study. [PDF]

BMC Neurol
von Alvensleben AC, Buring JE, Schulz RS, Filser PJ, Kang JH, Rist PM, Kurth T.   +6 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Classification of daily activities using a wireless instrumented insole (WalkinSense) in a semi free-living setting. [PDF]

PLoS One
Backes A, Eckelt M, Fayad J, Serchi V, Solignac T, Meyer T, Grimm B, Mouton C, Seil R, Malisoux L.   +9 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

In-field habitat diversification increases arthropod species richness and abundance in sweet corn. [PDF]

Environ Entomol
Yurchak V, Leslie A, McCluen SR, Hooks CRR.   +3 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Diagnostic accuracy of machine-learning-based image analysis for early detection of Kaposi sarcoma in people living with HIV. [PDF]

Front Artif Intell
Innocent DC, Innocent IP, Innocent RC.
europepmc   +1 more source

Prevalence and correlates of underweight among lactating mothers aged 20-49 years living in the Urban Slums of Kampala City, Uganda: A mixed-methods cross-sectional study. [PDF]

PLOS Glob Public Health
Magona Nerima S, Kirabo J, Nsubuga EJ, Nanyombi G, Komakech JJ, Musisi L, Mbabazi J, Ddamulira JB.   +7 more
europepmc   +1 more source

A bedside-to-outside model of human nutrition research. [PDF]

Cell Metab
Hengist A, Chung ST, Darcey VL, Chen K, Guo J, Frost G, Gonzalez JT, Hall KD.   +7 more
europepmc   +1 more source

Integrating Wearable Temperature, Activity, Melanopic Light, and Lifelog Data to Assess Circadian-Behavioral Coupling in Free-Living Conditions. [PDF]

Sensors (Basel)
Matsumoto S, Hashimoto Y, Nishida Y.
europepmc   +1 more source