Results 71 to 80 of about 202,245 (252)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Comparative analysis of intraoperative fluoroscopic vs. Anatomical landmark positioning methods in MPFL reconstruction for recurrent patellar dislocation

BMC Musculoskeletal Disorders
Objective A retrospective analysis was conducted to evaluate the application of the intraoperative fluoroscopic positioning and anatomical landmark positioning methods in medial patellofemoral ligament (MPFL) reconstruction for recurrent patellar ...
Ruke Lin, Ping Fu, Xinfu Zhang, Yajie Wu, Xibei Lin, Daohong Zhao   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Augment BeiDou real-time precise point positioning using ECMWF data

Earth, Planets and Space, 2018
The Chinese BeiDou Navigation Satellite System has shown potential for precise positioning with a comparable accuracy to that of the Global Positioning System (GPS) at the centimeter level for the horizontal component and the sub-centimeter level for the
Kemin Zhu, Lei Zhao, Wei Wang, Shoujian Zhang, Renli Liu, Jinling Wang   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

myGNSS: A real-time high-accuracy positioning app with android smartphones

SoftwareX
This work presents myGNSS, the first open-source, true real-time positioning application for Android smartphones. The developed app integrates three core functionalities: (1) acquisition and logging of raw Global Navigation Satellite System (GNSS ...
Yufeng Jin, Wenlin Yan, Jiahao Zhu, Luísa Bastos   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Study of regional ionospheric structures and their impacts on SPP and PPP with multi-instrument observations in the Asian sector

Satellite Navigation
Regional ionospheric structures characterized by localized spatial variations in plasma density significantly impact radio signals and Global Navigation Satellite System (GNSS) applications.
Bowei Liu, Libo Liu, Ang Liu, Yuyan Yang, Xiukuan Zhao, Zishen Li, Xinan Yue, Jing Liu, Huijun Le, Yiding Chen, Ruilong Zhang, Wenbo Li   +11 more
doaj   +1 more source