Results 71 to 80 of about 51,445,664 (248)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Unraveling the dose-dependent mechanisms of nicotine on humification during tobacco waste composting: Insights from microbial ecology and metabolic partitioning

Industrial Crops and Products
The inherent toxicity and wide-ranging concentrations of nicotine severely impede the predictable and efficient valorization of tobacco waste via composting.
Dandan Liu, Xinxin Ma, Shaoqi Xu, Hongru Xi, Chenqi Niu, Kuo Huang, Dong Li, Yiying Jin, Changwen Ye   +8 more
doaj   +1 more source

Optimization of Phenolic in Extraction Kasturi Mango Leaves (Mangifera casturi Kosterm.) with Taguchi Method [PDF]

BIO Web of Conferences
Kasturi mango (Mangifera casturi Kosterm.) is one of specific germplasm in South Kalimantan which in the category threatened with extinction. This plant has active metabolites such as phenolic groups which potentially to be bioactive.
Budiarni Kasandra, Furnawanthi Hindaningrum Irni, Kartiman Roni, Maily, Anggita Raharjani Sophie, Sri Pambayun Fauziah, Rahmadi Putra Aufadil, Angga Valentino Herly, Putri Sulastry Dwi   +8 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Analysis on Energy Conservation and Carbon Reduction Potential of Road and Tunnel LED Lighting Driven by GB 37478 Standard and Its Policy Implications

Energies
With China’s accelerated urbanization, road and tunnel lighting demand and its electricity consumption have grown significantly, making energy conservation, and carbon reduction urgent.
Xiuying Liang, Lei Zeng, Jialin Liu, Rui Wang, Ren Liu   +4 more
doaj   +1 more source

Chemical exposure assessment in children's stickers based on fuzzy analytic hierarchy process [PDF]

E3S Web of Conferences
Safety analysis was conducted on harmful substances such as formaldehyde, plasticizer, migratable elements, SCCPs, benzene series, etc., that may pose risks and hazards in children's sticker products. According to the chemical exposure assessment methods
Chen Qianwen, Wei Linlin, Wang Kunran, Liu Xia, Li Ying   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Unified waveform design for 6G low-power systems

物联网学报
Technologies such as ambient Internet of things (AIoT), low power wide area (LPWA), and low power wake up signal and radio (LP-WUS/WUR) are key enablers for low power system design.
Huang Wei, Tan Junjie, Jiang Dajie, Wang Wei   +3 more
doaj  

Analysis and prospects for blockchain testing and evaluation [PDF]

Blockchain
With the strong support of various countries’ policies, blockchain technology is booming in all walks of life, and the demand for blockchain evaluation is also growing.
Peiyu Zheng, Mengwei Han, Haiyan Kuang, Heng Yuan, Xiaofeng Chen   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source