Results 41 to 50 of about 341,499 (215)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives

Pain and Therapy
The multifaceted nature of osteoarthritis (OA) pain presents a challenge in understanding and managing the condition. The diverse pain experiences, progression rates, individual responses to treatments, and complex disease mechanisms contribute to ...
Vidhu Sethi, Chetan Anand, Oscar Della Pasqua   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Method for Designing a Patient Burden Questionnaire in Dermatology

Clinical, Cosmetic and Investigational Dermatology, 2020
Khaled Ezzedine,1 Mohammed Bennani,2 Jason Shourick,3 Charles Taieb4,5 1University Hospital Henri-Mondor, Department of Dermatology, Créteil, France; 2Qualees, Paris, France; 3University of Paris-Sud, Paris, France; 4Necker Enfants Malades ...
Ezzedine K, Bennani M, Shourick J, Taieb C   +3 more
doaj  

Let There Be PEACE: Improving Continuous Symptom Monitoring in Hospice Patients

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2020
Objective: To ensure that a standardized method of continuous symptom monitoring was available to hospice patients enrolled at our institution. Patients and Methods: The Palliative/End-of-Life/Assessment/Care Coordination/Evidence-Based Program (PEACE ...
Cory Ingram, MD, MS, Charles J. Bruce, MD, Erin L. Shadbolt, MSN, RN, Erin Mahnke, MHA, Adam Darkins, MD, Sheri Dodd, MS, Lindsay M. Streeter, RN, BSN, CHFN, ICST   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Assessment of the current practice of antibiotic skin testing in a tertiary Hospital in United Arab Emirates

Journal of Infection in Developing Countries, 2011
Introduction: Skin testing can be a useful diagnostic tool to identify patients who are allergic to penicillin. Procedures for skin testing in the United Arab Emirates have not been standardized. The aim of this study was to examine the current practice
Shemeena AbdulAzeez, Ghada Khalil Al Tajir, Hana Sulieman   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Impact of standardized penicillin therapy on pregnancy outcomes in maternal syphilis: a retrospective cohort study (2013–2023)

Journal of Infection in Developing Countries
Introduction: The aim of this study was to assess the impact of standardized benzathine penicillin therapy on adverse pregnancy outcomes in high-titer toluidine red unheated serum test (TRUST) positive (≥ 1:16) syphilis cases and refine prevention of ...
Xiaolin Li, Yan Ji
doaj   +1 more source