Results 71 to 80 of about 341,499 (215)

Point Prevalence Survey of Antibiotic Use in Latin American Hospitals: 2022–2023

Antibiotics
Background: Antimicrobial resistance (AMR) is a public health challenge, exacerbated by the inappropriate use of antibiotics (ABs) and the lack of standardized surveillance in healthcare settings.
Paola Lichtenberger, Gabriel Levy-Hara, Robin Rojas-Cortés, Tatiana Orjuela, Jose Pablo Diaz-Madriz, Pilar Ramon-Pardo, Jose Luis Bustos, Anahí Dreser, Tania Herrera, Marcela Pilar Rojas-Diaz, Giovanna Huaquipaco, Didia Sagastume, Jose Luis Castro, on behalf of the Latin American PPS Group   +13 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

A multidisciplinary and structured approach for comprehensive evaluation of functional outcomes, adverse events, psychosocial outcomes and health-related quality of life after local therapy for bone sarcoma in children: protocol for a cross-sectional study

Frontiers in Pediatrics
IntroductionBone sarcoma patients face intensive treatment, including life-changing local therapy, which impacts both short- and long-term functioning.
Leonie G. Tigelaar, Lianne M. Haveman, Willem P. Bekkering, Irene L. B. Oude Lansink, Christel D. Rohrich, Hinke Van der Hoek, Laura R. Beek, Jennifer Van Dijk, Marjolein E. M. Langemeijer, Relinde W. Slooff-Lentink, Alied M. Van der Aa-Van Delden, Heleen Maurice-Stam, Annemarie M. L. Peek, Helena J. H. Van der Pal, Maria M. W. Koopman, Leontien C. M. Kremer, Stijn J. Westerbos, Harm Van Tinteren, Jos A. M. Bramer, Jos A. M. Bramer, Michiel A. J. Van de Sande, Michiel A. J. Van de Sande, Martha A. Grootenhuis, Hendrik W. B. Schreuder, Hendrik W. B. Schreuder, Johannes H. M. Merks, Johannes H. M. Merks   +26 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Implementing a Manual for Neurofeedback Training in a Psychosomatic–Psychotherapeutic Outpatient Unit: A Mixed Methods Evaluation of Acceptance, Satisfaction and Feasibility in Patients and Practitioners

Psychiatry International
Despite the evidence for the effectiveness of neurofeedback (NFB) treatment, standardization is scarce, impairing comparability across studies and conditions.
Miriam Karl, Hannah Göke, Axel Kowalski, Nora Dörrie, Eva-Maria Skoda, Alexander Bäuerle, Martin Teufel, Kira L. Schmidt   +7 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Towards a standardized reporting of the impact of magnetic resonance imaging on the decision-making of thoracolumbar fractures without neurological deficit: Conceptual framework and proposed methodology

Brain and Spine
Introduction: A recent meta-analysis showed that only four prior studies have shown that magnetic resonance imaging (MRI) can change the fracture classification in 17% and treatment decisions in 22% of cases.
Mohamed M. Aly, Sebastian F. Bigdon, Ulrich J.A. Speigl, Gaston Camino-Willhuber, Saleh Baeesa, Klaus J. Schnake   +5 more
doaj   +1 more source