Results 111 to 120 of about 254,559 (302)

Dual-tracer 18F-FDG and 18F-AlF-NOTA-octreotide PET/CT imaging in oncocytic thyroid adenoma: a case report and literature review

Frontiers in Endocrinology
Introductiononcocytic thyroid adenoma (OA), a rare benign neoplasm, poses diagnostic challenges in conventional imaging modalities. The study investigates the diagnostic utility of dual-tracer 18F-fluorodeoxyglucose (18F-FDG) and 18F-AlF-NOTA-octreotide (
Jing Li, Jing Li, Jing Li
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Micro-meso-macro practice tensions in using patient-reported outcome and experience measures in hospital palliative care [PDF]

, 2018
This article applies a micro-meso-macro analytical framework to understand clinicians’ experiences and perspectives of using patient-reported outcome and experience measures (PROMs and PREMs) in routine hospital-based palliative care.
Cohen, Robin, Krawczyk, Marian, Mercedes Laforest, Esther, Reimer-Kirkham, Sheryl, Sawatzky, Richard, Schick-Makaroff, Kara, Stajduhar, Kelli, Öhlen, Joakim   +7 more
core   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Improving the clinical value and utility of CGM systems: issues and recommendations : a joint statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group [PDF]

, 2017
The first systems for continuous glucose monitoring (CGM) became available over 15 years ago. Many then believed CGM would revolutionise the use of intensive insulin therapy in diabetes; however, progress towards that vision has been gradual.
Bergenstal, Richard M., Fleming, G. Alexander, Heinemann, Lutz, Holl, Reinhard W., Peters, Anne L., Petrie, John R.   +5 more
core   +2 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Quantitative evaluation of 67Ga-citrate scintigraphy in the management of nephritis

Scientific Reports
In 67Ga-citrate scintigraphy (Ga-S), visual assessment is used by evaluating renal-uptake comparison with liver and spine and is simple and objective. We adopted the standardized uptake value (SUV) for 67Ga-citrate and proposed two quantitative indices ...
Noritake Matsuda, Hideki Otsuka, Ryosuke Kasai, Tamaki Otani, Leah Anne Christine Locsin Bollos, Shota Azane, Yamato Kunikane, Yoichi Otomi, Yuya Ueki, Mana Okabe, Masafumi Amano, Masanori Tamaki, Shu Wakino, Shoichiro Takao, Masafumi Harada   +14 more
doaj   +1 more source

MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging -- design, implementation and application on the example of DCE-MRI

, 2019
Many medical imaging techniques utilize fitting approaches for quantitative parameter estimation and analysis. Common examples are pharmacokinetic modeling in DCE MRI/CT, ADC calculations and IVIM modeling in diffusion-weighted MRI and Z-spectra analysis
Abdollahi, Amir, Debus, Charlotte, Floca, Ralf, Ingrisch, Michael, Kompan, Ina, Maier-Hein, Klaus, Nolden, Marco   +6 more
core   +1 more source

Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model. [PDF]

, 2020
Molecules from animal venoms are promising candidates for the development of new drugs. Previous in vitro studies have shown that the venom of the spider Phoneutria nigriventer (PnV) is a potential source of antineoplastic components with activity in ...
Barreto, Natália, Bonfanti, Amanda Pires, Brunetto, Sérgio, Caballero, Marcus, Cordeiro, Gabriel, Moura, Fernanda, Munhoz, Jaqueline, Ramos, Celso Dario, Rapôso, Catarina, Rocha-E-Silva, Thomaz, Sutti, Rafael, Thome, Rodolfo, Verinaud, Liana   +12 more
core   +1 more source

Metabolic and cardiovascular response to exercise in patients with type 1 diabetes [PDF]

, 2017
Physical activity is an effective therapeutic tool for cardiovascular risk prevention. However, exercise aerobic capacity of patients with type 1 diabetes (T1DM) has not been thoroughly investigated.
Bonini, Matteo, Filardi, Tiziana, Lenzi, Andrea, Marinelli, Paolo, Morano, Susanna, Palange, Paolo, Paris, Alberto, Rossetti, Marco, Statuto, G, Turinese, Irene   +9 more
core   +1 more source