Results 61 to 70 of about 118,834 (253)

Psoas muscle fluorine‐18‐labelled fluoro‐2‐deoxy‐d‐glucose uptake associated with the incidence of existing and incipient metabolic derangement

Journal of Cachexia, Sarcopenia and Muscle, 2019
Background Skeletal muscle glucose utilization is an important component of whole‐body glucose consumption in normal humans. Fluorine‐18‐labelled fluoro‐2‐deoxy‐d‐glucose (18F‐FDG) is a non‐invasive molecular imaging probe for evaluating tissue glucose ...
Ji Young Kim, Dae Won Jun, Jun Choi, Eunwoo Nam, Donghee Son, Yun Young Choi   +5 more
doaj   +1 more source

[18F]AV45 standardized uptake value ratio harmonization using ComBat in multi‐center cross‐sectional Alzheimer’s studies [PDF]

, 2023
Tahnia Nazneen, Stijn Servaes, Seyyed Ali Hosseini, Cécile Tissot, Nesrine Rahmouni, Joseph Therriault, Arthur C. Macedo, Dana Tudorascu, Pedro Rosa‐Neto   +8 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies [PDF]

, 2021
Hiromitsu Daisaki, Kazuhiro Kitajima, Masatoyo Nakajo, Tadashi Watabe, Kimiteru Ito, Fumi Sakamoto, Tadaki Nakahara, Mana Ishibashi, Akira Toriihara   +8 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy: the OVOID Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Myocardial metabolism plays an important role in maintaining cardiac function. Patients with dilated cardiomyopathy exhibit alterations in myocardial metabolism characterized by increased myocardial glucose metabolism.
Sangyong Jo, Kyungil Park, Jae Hyuk Choi, Chang‐Bae Sohn, Jeonghwan Kim, Yong‐Seop Kwon, Su Hong Kim, Tae‐ho Park   +7 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Dual-tracer 18F-FDG and 18F-AlF-NOTA-octreotide PET/CT imaging in oncocytic thyroid adenoma: a case report and literature review

Frontiers in Endocrinology
Introductiononcocytic thyroid adenoma (OA), a rare benign neoplasm, poses diagnostic challenges in conventional imaging modalities. The study investigates the diagnostic utility of dual-tracer 18F-fluorodeoxyglucose (18F-FDG) and 18F-AlF-NOTA-octreotide (
Jing Li, Jing Li, Jing Li
doaj   +1 more source