Results 91 to 100 of about 27,294,563 (294)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Structural Equation Modeling of Musculoskeletal Pains, Work–Family Conflict, and Sleep-Related Problems on Well-Being of Food Manufacturing Workers

open access: yesApplied Sciences
The objective of this study is to investigate the causal relationships between musculoskeletal pains, work–family conflict, sleep-related problems, and the well-being of food manufacturing workers using structural equation modeling.
Jun Won Kim, Byung Yong Jeong
doaj   +1 more source

Development and evaluation of a standardized peer-training in the context of peer review for quality assurance in work capacity evaluation

open access: yesBMC Medical Education, 2018
Background The German quality assurance programme for evaluating work capacity is based on peer review that evaluates the quality of medical experts’ reports. Low reliability is thought to be due to systematic differences among peers.
André Strahl   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Proceedings of the Sixteenth National Symposium on Doctoral Research in Social Work [PDF]

open access: yes, 2004
The University Archives has determined that this item is of continuing value to OSU's history.The Ohio State University College of Social WorkFront matter: Proceedings title, table of contents ...
Ohio State University. College of Social Work
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

United War Work Campaign Subscription form No. 11309

open access: yes, 1918
A United War Work Campaign Subscription form, No. 11309, from World War I. The form was is filled out for 5 dollars which was paid on December 11, 1918. It is signed by the solicitor M.
United War Work Campaign
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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