Results 191 to 200 of about 27,294,563 (294)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries. [PDF]

Adv Sci (Weinh)
Sun C, Wei S, Tao J, Chen H, Yan C, Wang J, Xu J, Duan L, Zhan Y, Zou Y, Li R, Yuan L, She W, Lu S, Wang N, Ren Q, Guo Y, Xu Y, Wang C, Tian H, Zhang C, Dong Y, Tang G, Shang Z, Jiang Y, Lv W, Zhang M, Lyu H.   +27 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Association between police work stress and life satisfaction: the chain mediating roles of perceived social support and sleep disturbances. [PDF]

Front Psychol
Qiu J, Lai X, Deng J, Wang K.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Correlation between organizational identity and quality of work life of nurses receiving standardized training in special departments

Huli yanjiu, 2020
WANG Xiumei, WEI Ling, JIANG Weilian
doaj  

A Cautious Integration With AI in the Clinic: A Standardized-Patient Pilot Study of ChatGPT's Reliability in Hamilton Depression Rating Scale Scoring. [PDF]

Alpha Psychiatry
Chang CH, Cheng SW, Chen WJ, Chang CW, Liu TH, Lee JH, Lin SC, Su KP.   +7 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

How Perceived Team Job Crafting Relates to Nurses' Thriving at Work: Indirect Associations Through Work Capital and Decent Work. [PDF]

Int Nurs Rev
Lv W, Wang Y, Feng Y, Luo H, Zheng J, Huang X, Xue B.   +6 more
europepmc   +1 more source