Results 61 to 70 of about 169,879,036 (291)

The Role of Financial Control in New Product Development: Empirical Insights into Project Managers' Experiences

, 2016
This paper explores financial control in new product development (NPD) project managers’ work. To supplement previous literature on controlling innovation activities, the paper focuses on NPD project managers’ versatile role of being under control (about
Tervala, Emmi, Laine, Teemu, Korhonen, Tuomas, Suomala, Petri   +3 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Information systems management maturity and information technology security effectiveness [PDF]

, 2004
vii, 129 leaves ; 29 cm.Modern societies rely on Information Systems (IS), yet their protection has long been considered ineffective. Researchers and practitioners have struggled to understand the persistence of this phenomenon, but both agree that IS ...
Spicer, Garry, University of Lethbridge. Faculty of Management   +1 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

MARY H. SAUNDERS

, 2020
NBS/NIST: 1993–2008 and 2011–2017 INDUCTED into the NIST Gallery of Distinguished Scientists, Engineers, and Administrators: 2020 Birth: 1955, Falls Church, Virginia EDUCATION: Vanderbilt University, BA (Political Science), 1977 Princeton University ...
National Institute of Standards and Technology
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

IFLA Standards Procedures Manual

, 2014
The IFLA Standards Procedures Manual provides guidance for the development and revision of standards and guidelines by IFLA professional units. It seeks to establish: how to present the need for specific standards and guidelines; maximize consensus about
IFLA Working Group of Committee on Standards
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A Self‐Monitoring Mobile App to Mitigate Risk Factors for Suicide and Self‐Harm in Junior (Resident) Doctors: A Review, Thematic Analysis and Concept Proposal

Healthcare Technology Letters
Doctors, particularly those in training in the UK, are exposed to high levels of stress in their work, which can lead to burnout and mental health problems.
Kirsten Leslie, Chloe Sawyer, Katy Oak, Gareth Lewis, Bryan Clark, Anna Mankee‐Williams, Ellen Wilkinson, Hiu Lam, Richard Laugharne, Rohit Shankar   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source