Results 41 to 50 of about 965,260 (357)

Questioning the Standard of Proof [PDF]

Journal of International Criminal Justice, 2015
The article begins with a discussion of the judicial debate on the confirmation procedure before the International Criminal Court, which arose in the pretrial proceedings in the Gbagbo case. The author argues that in finding that a confirmation of the charges decision should be based on ‘the strongest possible case based on a largely completed ...
openaire   +2 more sources

Decision Analysis and FDA Drug Review: A Proposal for Shadow Advisory Committees [PDF]

, 1995
The FDA seems to acknowledge that sometimes different standards of proof for assessing drug efficacy should be used. Dr. Mendeloff thus proposes a methodology that might illuminate the FDA\u27s decision-making and help better to assess its ...
Mendeloff, John M.
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The BARD Standard

Quaestio Facti
The work comments on Della Torre’s essay about the evolution of the reasonable doubt criminal standard of proof. By going through the main claims of the essay, which is both historical and theoretical, the work contends that the essay clarifies (and ...
Giovanni Tuzet
doaj   +1 more source

Status and prospect of microcomputer protection device for mine-used high-voltage explosion-proof switch

Gong-kuang zidonghua, 2018
Status of microcomputer protection device for mine-used high-voltage explosion-proof switch was introduced from aspects of hardware structure and basic functions.
LU Donggui, RONG Xiang, ZENG Ke
doaj   +1 more source

The future of social is personal: the potential of the personal data store [PDF]

, 2014
This chapter argues that technical architectures that facilitate the longitudinal, decentralised and individual-centric personal collection and curation of data will be an important, but partial, response to the pressing problem of the autonomy of the ...
A. Bandura, A. Doan, A. Fung, A. Nadkarni, A. Narayanan, A.K. Dey, D. Purdue, D.R. Karger, E. McCallister, G. Huang, J. Teevan, J.M. Agustin, L. Floridi, L.A. Bygrave, M.A. Grasso, N. Williams, P. Ohm, P. Pirolli, P. Pirolli, P. Vakkari, R. Ennals, R.A. Posner, R.R. Schaller, S. Whittaker, T. Heath, V. Bush, V. Mayer-Schönberger, W. Jones   +27 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Certifying RSA public keys with an efficient NIZK [PDF]

, 2018
In many applications, it is important to verify that an RSA public key ( N,e ) specifies a permutation, in order to prevent attacks due to adversarially-generated public keys.
Balditimsi, Foteini, Goldberg, Sharon, Reyzin, Leonid, Sagga, Omar   +3 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source