Results 41 to 50 of about 125,304 (264)

DOES IT EXIST (AND SHOULD IT EXIST) A BALANCE OF PUBLIC AND PRIVATE PRINCIPLES IN RUSSIAN CRIMINAL PROCEEDINGS?

Правовое государство: теория и практика
In order to effectively fulfil state tasks in the field of activities of criminal justice authorities, a legislative definition of a reasonable correlation between public and private principles is required both in criminal procedure legislation and in ...
AZAROV Vladimir Alexandrovich
doaj   +1 more source

jsCoq: Towards Hybrid Theorem Proving Interfaces [PDF]

Electronic Proceedings in Theoretical Computer Science, 2017
We describe jsCcoq, a new platform and user environment for the Coq interactive proof assistant. The jsCoq system targets the HTML5–ECMAScript 2015 specification, and it is typically run inside a standards-compliant browser, without the need of external ...
Emilio Jesús Gallego Arias, Benoît Pin, Pierre Jouvelot   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Plausibility, Facts and Economics in Antitrust Law [PDF]

Yearbook of Antitrust and Regulatory Studies, 2014
According to EU competition law, the existence of an anticompetitive agreement can be inferred from a number of coincidences and indicia only in the absence of another plausible explanation of the facts at stake. According to U.S.
Mariateresa Maggiolino
doaj  

Good for your health? An analysis of the requirements for scientific substantiation in European health claims regulation

Salud Pública de México, 2016
Objective. To identify the various types of evidence, as well as their relative importance in European health claims regulation, in order to analyze the consequences for consumer protection of the requirements for scientific substantiation in this ...
Oliver Todt, José Luis Luján
doaj   +1 more source

The civil standard of proof—what is it, actually? [PDF]

The International Journal of Evidence & Proof, 2013
Unlike common law, Continental European civil law does not strictly distinguish between the standards of proof applicable in civil and criminal matters, respectively. In civil law countries such as Germany and Switzerland, judges are supposed to use the same (high) standard of ‘full conviction’ in both criminal and civil cases. This study is the first
openaire   +5 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source