Results 71 to 80 of about 351,149 (250)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Effectiveness and time-course adaptation of resistance training vs. plyometric training in prepubertal soccer players

Journal of Sport and Health Science, 2020
Purpose: This study aimed to assess the effectiveness and time course for improvements in explosive actions through resistance training (RT) vs. plyometric training (PT) in prepubertal soccer players.
Yassine Negra, Helmi Chaabene, Thomas Stöggl, Mehréz Hammami, Mohamed Souhaiel Chelly, Younés Hachana   +5 more
doaj   +1 more source

UJI VALIDITAS DAN RELIABILITAS INSTRUMEN TES FISIK KURIKULUM DAN PEDOMAN DASAR SEPAKBOLA INDONESIA [PDF]

, 2016
Tujuan penelitian ini adalah untuk mengetahui nilai validitas dan reabilitas suatu alat ukur yang digunakan untuk tes fisik sepakbola usia 19 tahun. Metode yang digunakan dalam penelitian ini adalah metode deskriptif.
Nurulhuda, Fauzi Ahmad
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

DIFFERENCES IN THE LEVEL OF STRENGTH WITH STUDENTS OF DIFFERENT SPORTS DIRECTIONS [PDF]

Sport Mont, 2008
On a specimen of 114 tested boys, aged 15, of which 38 tested boys were footballers, 38 basketball players and 38 students who do not practice a sport, the determination of differences in three motoric tests (standing long jump, standing triple jump and ...
Tijana Krsmanović, Radenka Kovačević, Maja Batez   +2 more
doaj  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The Factor Structure of Coordination Abilities Development in 5th-7th Grade Boys

Physical Education Theory and Methodology, 2017
The objective is to determine the structure of coordination abilities development in 5th-7th grade boys. Materials and methods. The participants in the study were boys of the 5th grade (n=21), 6th grade (n=20), and 7th grade (n=19).
В. В. Приходько
doaj   +1 more source

Associations between Fitness Measures and Change of Direction Speeds with and without Occupational Loads in Female Police Officers [PDF]

, 2019
Female police officers may be required to pursue offenders on foot while wearing occupational loads. The aim of this study was to determine relationships between fitness measures and change of direction speed (CODS) in female police officers and the ...
Dawes, Jay, Janković, Radivoje, Koropanovski, Nenad, Kukić, Filip, Lockie, Robert, Orr, Robin M., Čvorović, Aleksandar   +6 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Unveiling the relationship of physical literacy with muscular fitness and muscle-strengthening activities in adolescents: the EHDLA study

BMJ Open Sport & Exercise Medicine
Objective This study evaluated the relationship between physical literacy (PL) and muscular fitness (MF) as well as muscle-strengthening activities (MSA) in adolescents.Methods A secondary cross-sectional study included 823 adolescents (45.1% boys) from ...
Emilio Villa-González, Avery D Faigenbaum, José Francisco López-Gil   +2 more
doaj   +1 more source