Results 101 to 110 of about 881,385 (277)

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Population Pharmacokinetic and Pharmacodynamic Analysis for Maximizing the Effectiveness of Ceftobiprole in the Treatment of Severe Methicillin-Resistant Staphylococcal Infections. [PDF]

Microorganisms, 2023
Cojutti PG, Giuliano S, Pascale R, Angelini J, Tascini C, Viale P, Pea F.   +6 more
europepmc   +1 more source

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Targeting staphylococcal bone infections

MedComm – Biomaterials and Applications, 2023
Zhang Xiangchun, Xulin Hu, Hongping Chen
doaj   +1 more source

Epidemiology of community-onset Staphylococcus aureus infections in pediatric patients: an experience at a Children's Hospital in central Illinois

BMC Infectious Diseases, 2009
Background The nation-wide concern over methicillin-resistant Staphylococcus aureus (MRSA) has prompted many clinicians to use vancomycin when approaching patients with suspected staphylococcal infections.
Gray Barry M, Mankin Peggy, Aldag Jean C, Mongkolrattanothai Kanokporn   +3 more
doaj   +1 more source

TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia [PDF]

, 2010
Background: Staphylococcus epidermidis (SE) is a nosocomial pathogen that causes catheter-associated bacteremia in the immunocompromised, including those at the extremes of age, motivating study of host clearance mechanisms. SE-derived soluble components
Gallington, LC, Levy, O., Stoler-Barak Liat, Currie, A.J., Golenbock Douglas T., Golenbock, D.T., Melanie R Power Coombs, Otto, M, Gallington, Leighanne C., Burgner David, Levy, Ofer, Power Coombs, Melanie R., Richmond Peter, Currie, AJ, Douglas T Golenbock, Andrew J Currie, Power Coombs, M.R., Gallington, L.C., Strunk, Tobias, Stoler-Barak, L, Burgner, D., Burgner, D, Leighanne C Gallington, Golenbock, DT, Otto, Michael, Power Coombs Melanie R., Otto Michael, Currie, Andrew J., Richmond, P., Levy Ofer, Ofer Levy, Strunk Tobias, Otto, M., Liat Stoler-Barak, Tobias Strunk, Stoler-Barak, L., Burgner, David, Currie Andrew J., Richmond, Peter, Levy, O, Strunk, T, David Burgner, Coombs, MRP, Stoler-Barak, Liat, Peter Richmond, Strunk, T., Michael Otto, Richmond, P, Golenbock, Douglas T., Gallington Leighanne C.   +49 more
core   +2 more sources

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Exebacase: A Novel Approach to the Treatment of Staphylococcal Infections. [PDF]

Drugs R D, 2022
McCarthy MW.
europepmc   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Occurrence of Staphylococcal Ocular Infections of Food Producing Animals in Nsukka Southeast, Nigeria

Veterinary Medicine International, 2014
Staphylococcal ocular infections of food animals have been somewhat under diagnosed probably due to the ubiquitous nature of staphylococcal organisms.
Sunday Ositadinma Udegbunam, Rita Ijeoma Udegbunam, Madubuike Umunna Anyanwu   +2 more
doaj   +1 more source