Results 51 to 60 of about 57,599 (257)

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Manuka honey as a non-antibiotic alternative against Staphylococcus spp. and their small colony variant (SCVs) phenotypes

Frontiers in Cellular and Infection Microbiology
The antibiotic resistance (ABR) crisis is an urgent global health priority. Staphylococci are among the problematic bacteria contributing to this emergency owing to their recalcitrance to many clinically important antibiotics. Staphylococcal pathogenesis
Laura A. Onyango, Jiawei Liang
doaj   +1 more source

Fusidic acid and clindamycin resistance in community-associated, methicillin-resistant Staphylococcus aureus infections in children of Central Greece

BMC Infectious Diseases, 2010
Introduction In Greece, fusidic acid and clindamycin are commonly used for the empiric therapy of suspected staphylococcal infections. Methods The medical records of children examined at the outpatient clinics or admitted to the pediatric wards of the ...
Petinaki Efi, Pournaras Spyros, Tsantsaridou Angeliki J, Grivea Ioanna N, Katopodis George D, Syrogiannopoulos George A   +5 more
doaj   +1 more source

Multifunctional Wound Dressings: Melt Electrowritten Scaffolds Combined With Phytotherapeutic Composite Hydrogels

Advanced Materials Interfaces, EarlyView.
ABSTRACT The increasing prevalence of impaired wounds, caused mainly by diabetes or aging, alongside the growing number of bacterial infections, indicates the need for alternative tissue engineering solutions. In this study, we developed novel melt electrowritten (MEW) polycaprolactone (PCL) scaffolds incorporated with an alginate (Alg)–gelatin (Gel ...
Andrada‐Ioana Damian‐Buda, Aldo Roberto Boccaccini, Irem Unalan   +2 more
wiley   +1 more source

Facing Antibiotic Resistance: Staphylococcus aureus Phages as a Medical Tool

Viruses, 2014
Staphylococcus aureus is a common and often virulent pathogen in humans. This bacterium is widespread, being present on the skin and in the nose of healthy people.
Zuzanna Kaźmierczak, Andrzej Górski, Krystyna Dąbrowska   +2 more
doaj   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

Staphylococcus aureus Internalized by Skin Keratinocytes Evade Antibiotic Killing

Frontiers in Microbiology, 2019
Staphylococcus aureus causes the majority of skin and soft tissue infections. Half of patients treated for primary skin infections suffer recurrences within 6 months despite appropriate antibiotic sensitivities and infection control measures.
Arwa Al Kindi, Arwa Al Kindi, Abdullah M. Alkahtani, Mayimuna Nalubega, Mayimuna Nalubega, Cecile El-Chami, Catherine O’Neill, Peter D. Arkwright, Peter D. Arkwright, Joanne L. Pennock, Joanne L. Pennock   +10 more
doaj   +1 more source

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source