Results 41 to 50 of about 675,207 (304)

Four temperate bacteriophages from methicillin-resistant staphylococcus aureus show broad bactericidal and biofilm removal activities [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020
The emergence of multi-drug resistance among many bacteria including zoonotic pathogens in the food chain poses a growing public health threat to humans, animals, and the environment worldwide.
Mujib A. ABDURAHMAN, İlknur TOSUN, İnci DURUKAN, Mona KHORSHIDTALAB, Ali O. KILIÇ   +4 more
doaj   +1 more source

The distribution of plasmids that carry virulence and resistance genes in Staphylococcus aureus is lineage associated. [PDF]

, 2012
BACKGROUND: Staphylococcus aureus is major human and animal pathogen. Plasmids often carry resistance genes and virulence genes that can disseminate through S. aureus populations by horizontal gene transfer (HGT) mechanisms. Sequences of S.
McCarthy, AJ, Lindsay Jodi A, Lindsay, JA, Jodi A Lindsay, McCarthy Alex J, Alex J McCarthy   +5 more
core   +1 more source

New and old oxazolidinones: tedizolid vs. linezolid [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2017
Tedizolid is a novel oxazolidinone that has been recently approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) caused by Gram-positive pathogens, including MRSA.
Dekhnich A.V., Hachatryan N.N.
doaj  

Identification of a highly transmissible animal-independent Staphylococcus aureus ST398 clone with distinct genomic and cell adhesion properties. [PDF]

, 2012
A methicillin-resistant Staphylococcus aureus (MRSA) clone known as ST398 has emerged as a major cause of acute infections in individuals who have close contact with livestock.
Hirschberg, DL, Uhlemann, AC, Sullivan, SB, Lowy, FD, Kennedy, AD, Lipkin, WI, McCarthy, AJ, Street, C, Lindsay, JA, DeLeo, FR, Porcella, SF, Hafer, C, Trivedi, S, Barbian, KD   +13 more
core   +1 more source

Whole-genome sequencing reveals clonal expansion of multiresistant Staphylococcus haemolyticus in European hospitals [PDF]

, 2014
Objectives Staphylococcus haemolyticus is an emerging cause of nosocomial infections, primarily affecting immunocompromised patients. A comparative genomic analysis was performed on clinical S.
Kahlke, Tim, Flægstad, Trond, Jorunn Pauline Cavanagh, Matthew T. G. Holden, Tim Kahlke, Johanna U. Ericson Sollid, Holden, Matthew T G, Hjerde, Erik, Parkhill, Julian, Klingenberg, Claus, Claus Klingenberg, Cavanagh, Jorunn Pauline, Stephen D. Bentley, Erik Hjerde, Parkhill, J, Trond Flægstad, Sollid, Johanna U Ericson, Bentley, Stephen D, Julian Parkhill, Holden, Matthew T.G., Holden, MTG, Hjerde, E, Kahlke, T, Cavanagh, JP, Bentley, SD, Klingenberg, C, Ericson Sollid, JU, Flægstad, T, Holden, Matthew T G; id_orcid   +28 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Genome sequence survey identifies unique sequences and key virulence genes with unusual rates of amino Acid substitution in bovine Staphylococcus aureus [PDF]

, 2002
Staphylococcus aureus is a major cause of mastitis in bovine and other ruminant species. We here present the results of a comparative genomic analysis between a bovine mastitis-associated clone, RF122, and the recently sequenced human-associated clones ...
Kapur, Vivek, Chakravarty, Rajit, Musser, James M, Dwan, Christopher, Herron, Lisa L, Fitzgerald, J Ross; id_orcid, Retzel, Ernest   +6 more
core  

Impact of target site distribution for Type I restriction enzymes on the evolution of methicillin-resistant Staphylococcus aureus (MRSA) populations. [PDF]

, 2013
A limited number of Methicillin-resistant Staphylococcus aureus (MRSA) clones are responsible for MRSA infections worldwide, and those of different lineages carry unique Type I restriction-modification (RM) variants.
Dryden, David T. F., White, John H., Stephanou, AS, Cooper, Laurie P., Cooper, LP, Houston, PJ, Lindsay, JA, Chen, K, Dryden, DT, Roberts, Gareth A., Lindsay, Jodi A., Chen, Kai, Roberts, GA, White, JH, Stephanou, Augoustinos S., Houston, Patrick J.   +15 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evolutionary trade-offs underlie the multi-faceted virulence of Staphylococcus aureus [PDF]

, 2015
Date of Acceptance: 20/07/2015Bacterial virulence is a multifaceted trait where the interactions between pathogen and host factors affect the severity and outcome of the infection. Toxin secretion is central to the biology of many bacterial pathogens and
Williams, Barnabas, Uhlemann, Anne-Catrin, Edward Feil, Recker, Mario, Maisem Laabei (311431), Janina Dordel (250569), Janina Dordel, Votintseva, Antonina A., Lowy, Franklin D., Wilson, Daniel J, Bowden, Rory, Wilson, Daniel J., Daniel J. Wilson (194149), Matthew Holden, Crook, Derrick W., Dordel, Janina, Derrick W Crook, Maho Yokoyama (791513), Thorpe, Harry A, Holden, Matthew, Matthew Holden (791517), Sharon J. Peacock (35782), Derrick W. Crook (145636), Austin, Eloise D, Mario Recker (88496), Sharon J Peacock, Eloise D Austin, Perkins, Mark, Votintseva, Antonina A, Barnabas Williams (791515), Mario Recker, Franklin D Lowy, Young, Bernadette C, Khadija Ouadi, Ouadi, Khadija, Eloise D. Austin (791512), Rory Bowden (179995), Barnabas Williams, Bernadette C Young, Maho Yokoyama, Yokoyama, Maho, Clark, Stephen Robert, Harry A Thorpe, Franklin D. Lowy (299074), Edward Feil (270047), Anne-Catrin Uhlemann, Stephen R Clarke, Antonina A Votintseva, Clarke, Stephen R, Peacock, Sharon J., Mark Perkins, Ruth C. Massey (174217), Maisem Laabei, Antonina A. Votintseva (791518), Harry A. Thorpe (791514), Austin, Eloise D., Peacock, Sharon J, Massey, Ruth C., Mark Perkins (254177), Bernadette C. Young (408943), Feil, Edward, Anne-Catrin Uhlemann (299063), Crook, Derrick W, Laabei, Maisem, Khadija Ouadi (598087), Lowy, Franklin D, Daniel J Wilson, Rory Bowden, Stephen R. Clarke (791516), Massey, Ruth C, Young, Bernadette C., Thorpe, Harry A., Ruth C Massey, Austin Eloise D., Recker Mario, Young Bernadette C., Clarke Stephen R., Laabei Maisem, Bowden Rory, Wilson Daniel J., Dordel Janina, Holden Matthew, Crook Derrick W., Ouadi Khadija, Lowy Franklin D., Williams Barnabas, Peacock Sharon J., Feil Edward, Votintseva Antonina A., Thorpe Harry A., Perkins Mark, Uhlemann Anne-Catrin, Yokoyama Maho, Massey Ruth C., Holden, Matthew; id_orcid   +94 more
core   +1 more source