Results 91 to 100 of about 600,038 (258)

Genome Sequence of a Recently Emerged, Highly Transmissible, Multi-Antibiotic- and Antiseptic-Resistant Variant of Methicillin-Resistant Staphylococcus aureus, Sequence Type 239 (TW) [PDF]

, 2010
The Sanger Institute is core funded by the Wellcome Trust. Funding for the sequencing of the TW20 genome was provided by Guy’s and St. Thomas’ Charity. J.D.E.
Edgeworth, Jonathan D., Quail, MA, Bentley, SD, Quail, Michael A., Parkhill, Julian, Corton, C, Parkhill, J, Lindsay, JA, Lindsay, Jodi A., Edgeworth, JD, Pathak, Smriti, Batra, R, Pathak, S, Bentley, Stephen D., Holden, MT, Holden, Matthew T. G., Cockfield, Joshua D., Batra, Rahul, Cockfield, JD, Corton, Craig   +19 more
core   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

Prevalence of Methicillin-Resistant Staphylococcus Aureus in El Oro Province, Ecuador [PDF]

, 2012
Color poster with text, images, tables, and graphs.Methicillin-resistant Staphylococcus aureus (MRSA) is an antibiotic-resistant strain of the bacterium Staphylococcus aureus.
Soderholm, Beatrice R., Monte, Christopher A.   +1 more
core  

Evaluation of spa-typing of methicillin-resistant Staphylococcus aureus using high-resolution melting analysis [PDF]

, 2015
OBJECTIVE: spa-typing of methicillin-resistant Staphylococcus aureus (MRSA) has been widely used in clinical diagnostics and epidemiological studies. We aimed to evaluate high-resolution melting (HRM) as a rapid and cost effective method, to replace DNA ...
Gunnar Sandstrom, Waleed Mazi, Vartul Sangal, Yu, J, Saeed, Amir, Sandstrom, Gunnar, Sangal, Vartul, Sangal, V, Sandstom, Gunnar, Amir Saeed, Mazi, W,, Jun Yu, Sandstrom, G, Saeed, A,, Mazi, Waleed, Yu, Jun   +15 more
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals [PDF]

, 2014
This work was supported by a Medical Research Council Partnership grant (G1001787/1) held between the Department of Veterinary Medicine, University of Cambridge (M.A.H.), the School of Clinical Medicine, University of Cambridge (S.J.P.), the Moredun ...
Andrew S. Waller, Boag, A K, Waller, Andrew S., John J. Welch, Sharon J. Peacock, Holden, Matthew T G, Wilson, Katherine, Parkhill, J, Harrison, Ewan M, Holmes, M A, Mark A. Holmes, Waller, Andrew S, Harris, Simon R., Welch, John J., Loeffler, Anette, Harris, Simon R, Boag, Amanda K, Holden, Matthew T. G., Peacock, Sharon J., Lucy A. Weinert, Harris, S R, Anette Loeffler, Morgan, F J E, Holden, M T G, Harrison, E M, Gavin K. Paterson, Paterson, Gavin; id_orcid, Katherine Wilson, Harrison, Ewan M., Ewan M. Harrison, Weinert, Lucy A., Peacock, Sharon J, Paterson, Gavin K., Fiona J. E. Morgan, Weinert, Lucy A, Loeffler, A, Waller, A S, Welch, J J, Simon R. Harris, Peacock, S J, Morgan, Fiona J E, Paterson, G K, Julian Parkhill, Amanda K. Boag, Matthew T. G. Holden, Paterson, Gavin K, Parkhill, Julian, Weinert, L A, Boag, Amanda K., Wilson, K, Welch, John J, Morgan, Fiona J. E., Holmes, Mark A, Holmes, Mark A.   +53 more
core   +2 more sources

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Epidemiological profile and antimicrobial resistance trends of Staphylococcus aureus in Chinese pediatric intensive care units from 2016 to 2022: a multi-center retrospective study

BMC Infectious Diseases
Objective This study aimed to analyze the profiles and evolution of Staphylococcus aureus in the pediatric intensive care units (PICUs) of 17 hospitals in China from 2016 to 2022.
Xiao-Lei Zhang, Jing Liu, Pan Fu, Yi-Xue Wang, Pan-Pan Fan, Jin-Lan Zhou, Xian-Qi Xiang, Hui-Li Shen, Ting-Yan Liu, Ying-Ying Zhang, Ting Zhu, Cai-Yan Zhang, Chuan-Qing Wang, Guo-Ping Lu, Gang-Feng Yan, the China paediatric Intensive care Unit Pathogen Surveillance Network (CHIPS) Study Group   +15 more
doaj   +1 more source

Carriage of Staphylococcus aureus in Thika Level 5 Hospital, Kenya: a cross-sectional study. [PDF]

, 2014
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen but little is known about its circulation in hospitals in developing countries. We aimed to describe carriage of S.aureus amongst inpatients in a mid-sized
Grundmann, Hajo, J Scott, Alexander M Aiken, Mwangi, Jonah, Jonah Mwangi, Susan C Morpeth, Morpeth, Susan C, Artur J Sabat, Akkerboom, Viktoria, Scott, J Anthony G, Aiken, Alexander M, Sabat, Artur J, Alexander W Friedrich, Mutuku, Irene M, Friedrich, Alexander W, Irene M Mutuku, Hajo Grundmann, Viktoria Akkerboom   +17 more
core   +2 more sources