Results 161 to 170 of about 600,038 (258)

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Design of a cyclic peptide targeting intracellular Staphylococcus aureus. [PDF]

Mol Biomed
Mourenza Á, Llano-Verdeja J, Castañera P, Krishnan R, Vogelaar A, Lorente-Torres B, Fernández-Martínez S, Ferrero HÁ, Zaro J, Aparicio JF, Mateos LM, de la Fuente-Nunez C, Letek M.   +12 more
europepmc   +1 more source

Affected Persons in Laboratory Exposures to Human Pathogens and Toxins in Canada, 2016–2024: A Sector‐Specific Analysis

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Exposures to human pathogens and toxins in licensed facilities in Canada have been monitored by a federal surveillance system since 2015, yet the affected persons (APs) in these incidents remain uncharacterized. This study comprehensively describes APs, highlighting sector‐specific patterns and trends over time.
Emily F. Tran, Christine Abalos, Antoinette N. Davis, Audrey Gauthier, Samuel Bonti‐Ankomah   +4 more
wiley   +1 more source

Chemoenzymatic Radiosynthesis of a Gluconate Transporter‐Targeted In Vivo Bacterial Sensor From Clinical [18F]FDG

Angewandte Chemie, EarlyView.
An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Sang Hee Lee, Jung Min Kim, Joseph Blecha, Robert R. Flavell, Michael A. Ohliger, Joanne Engel, Youngho Seo, David M. Wilson   +7 more
wiley   +2 more sources

Structural basis for the procoagulant activity of <i>Staphylococcus aureus</i> staphylocoagulase. [PDF]

Biol Chem
Fuentes-Prior P, Maddur AA, Panizzi P, Gailani D, Verhamme IM.   +4 more
europepmc   +1 more source

Host‐Specific Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa Impair Epithelial Repair in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun, Mahnaz Ramezanpour, George Bouras, Emma Barry, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +6 more
wiley   +1 more source

Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections

Angewandte Chemie, EarlyView.
KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran, Axia Marlin, Edith K. Amason, Marie Huynh, Hannah Carlisle, Eszter Boros   +5 more
wiley   +2 more sources

Rationalizing Heterogeneity in Staphylococcus aureus Bacteremia: Current Progress and Future Goals. [PDF]

J Infect Dis
Russell CD, De La Villa S, Swets MC, Westgeest AC, Zumbo G, Muñoz P, Dockrell DH, Fowler VG, Gutiérrez-Gutiérrez B.   +8 more
europepmc   +1 more source

Phenotypic characterization of inducible and constitutive clindamycin resistance in clinical Staphylococcus aureus isolates. [PDF]

Rev Inst Med Trop Sao Paulo
Rossi M, Benboubker M, Belchkar S, Yahyaoui G, Mahmoud M, Oumokhtar B.   +5 more
europepmc   +1 more source

Antibacterial and Immunomodulatory Activities of a Natural Polysaccharide Against <i>Staphylococcus aureus</i> Infection. [PDF]

Food Sci Nutr
Xia XC, Peng YQ, Liu LX, Cao B, Zhong XK, Wu XD, Liu T.   +6 more
europepmc   +1 more source