Results 131 to 140 of about 6,745 (290)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Interactive Prompt‐Guided Robotic Grasping for Arbitrary Objects Based on Promptable Segment Anything Model and Force‐Closure Analysis

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
A laser pointer‐guided robotic grasping method for arbitrary objects based on promptable segment anything model and force‐closure analysis is presented. Grasp generation methods based on force‐closure analysis can calculate the optimal grasps for objects through their appearances. However, the limited visual perception ability makes robots difficult to
Yan Liu, Yaxin Liu, Ruiqing Han, Kai Zheng, Yufeng Yao, Ming Zhong   +5 more
wiley   +1 more source

The Ergonomic Relationship Between Hand Size and Mesh Fixation Difficulty When Using Endoscopic Hernia Repair Staplers Based on a Questionnaire Survey [PDF]

Background There are few reports on the ergonomics of endoscopic hernia staplers. This study aimed to clarify the relationship between hand size and difficulty of stapler use. Methods Surgeons, who perform mesh fixation using endoscopic hernia staplers,
Keisuke FUKUI, Kohei TANIGUCHI, Sang-Woong LEE, Emiko KONO, Yuri ITO, Yoshiro IMAI, Kazuhisa UCHIYAMA   +6 more
core   +1 more source

Downsizing the Histone H3–H4 Quaternary Structure Into Foldamer Mimetics Yields High‐Affinity and Cell‐Permeable Ligands of ASF1

Angewandte Chemie, EarlyView.
We present a foldamer strategy to downsize the histone H3‐H4 quaternary structure into high‐affinity, medium‐sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide‐oligourea chimeras, designed through structure‐guided optimization and foldamer chemistry, recapitulate the natural H3‐H4 dimer binding mode while demonstrating plasma stability ...
Bo Li, Marie E. Perrin, Emma Maillard, Arthur Vitard, Gwenaëlle Moal, Johanne Mbianda, Christophe André, Magda Teixeira Nunes, Marie Vandamme, Guillaume Pinna, Céline Douat, Emmanuelle Thinon, Raphaël Guerois, Pierre Legrand, Gilles Guichard, Francoise Ochsenbein   +15 more
wiley   +2 more sources

Skin staplers versus skin sutures in elective and emergency abdominal surgeries: A Comparative clinical study [PDF]

, 2014
BACKGROUND: Patients whom underwent abdominal surgeries in both elective and emergency operation theatres in Tirunelveli Medical College Hospital was included in this prospective study.
Natarajan, M
core  

Quantifying Structure‐Dependent Rigidity of 3D DNA Origami Boxes

Advanced Intelligent Systems, EarlyView.
We investigate the mechanical stability of a hollow 3D DNA origami box during assembly using liquid AFM imaging and finite element simulations. As structural completeness increases from flat sheets through intermediate assemblies to a closed box, rigidity improves.
Judith Zubia‐Aranburu, Reza Zadegan, Jens Vinge Nygaard, Jørgen Kjems, Ramesh Subramani, Mingdong Dong   +5 more
wiley   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

Seeds of change: The impact of Ethiopia's direct seed marketing approach on smallholders' seed purchases and productivity

American Journal of Agricultural Economics, EarlyView.
Abstract While multiple factors explain low adoption rates of improved varieties by small‐scale farmers in sub‐Saharan Africa, a key supply‐side constraint is the limited availability of seed embodying new traits in the volume, quality, price, and timeliness required by farmers. This constraint is partly attributable to classical failures in the market
Dawit Mekonnen, Gashaw T. Abate, Seid Yimam, Rui Benfica, David J. Spielman, Frank Place   +5 more
wiley   +1 more source

Assessment of two-stage Duhamel procedure for Hirschsprung’s disease using two gastrointestinal staplers: An observational study

Background: Duhamel procedure (DP) is a popular surgical option for managing Hirschsprung’s disease (HD). In developing countries, the surgery can be performed in a two- or three-stage procedure.
Rahul Kumar Rai, Anand Pandey, Jiledar Rawat, Gurmeet Singh, Nitin Pant   +4 more
core   +1 more source

Lost in aggregation? On the importance of local food price data for food poverty estimates

American Journal of Agricultural Economics, EarlyView.
Abstract This paper explores within‐country variations in food price dynamics and food poverty estimates by employing local market price data and national consumer price index (CPI) data. Our results show that national CPI data may be useful for approximating national trends but they fail to detect and identify spatial variations in local trends, which
Stephan Dietrich, Valerio Giuffrida, Bruno Martorano, Georg Schmerzeck, Marco Tiberti   +4 more
wiley   +1 more source