Results 131 to 140 of about 1,177 (238)

Ground plan of Johannesburg railway station concourse level

, 1927
Proposed lower ground floor plan (concourse level) of the Johannesburg Railway Station [designed by architects Gerard Moerdijk and Gordon Leith]
Unknown
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Constructing an implementation plan for integrating green BIM into undergraduate architecture programs. [PDF]

Sci Rep
Ahmed N.
europepmc   +1 more source

New station : another view of the concourse

, 1927
Illustration of the concourse within the Johannesburg Railway Station, designed by architects Gerard Moerdyk and Gordon ...
Unknown
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Adapting to Modernity. River Engineering and Emotional Engineering in 1950s Sweden. [PDF]

NTM
Zimmer F.
europepmc   +1 more source

Babilonia, ida y vuelta: del rey arquitecto al arquitecto rey

, 2013
The (few) Mesopotamian architect-kings who -approaching to gods- used the sign DINGIR “star” happen to meet with the (many) king-architects of the (post)modernism in one point: his stellar vocation.
Sanmartín, Joaquín
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Mapping and Cataloguing Microbial and Biochemical Determinants of Health: Towards a 'Database of Salutogenic Potential'. [PDF]

Microb Biotechnol
Robinson JM, Brame J, Cando-Dumancela C, Deshmukh S, Fickling NW, Hawken S, Hayward C, Kuhn E, Lee K, Liddicoat C, Ramesh S, Robinson K, Sun X, Breed MF.   +13 more
europepmc   +1 more source

Empirical and quantitative studies of Feng Shui: A systematic review _{(PRISMA 2009 item 1)}. [PDF]

Heliyon, 2023
Han KT, Lin JK.
europepmc   +1 more source