Results 31 to 40 of about 15,738 (237)
GRAVITATIONAL WAVES: DETECTING RIPPLES IN SPACETIME
Worldwide Journal of Physics, 2022 Gravitational wave astronomy has emerged as a transformative domain in observational astrophysics, enabling direct detection of spacetime distortions caused by cataclysmic cosmic events such as black hole and neutron star mergers.
Farzana Majid +2 more
doaj
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
The Man in the Box (extract from The Shakespeare Riots)
19, 2009 One of the bloodiest incidents in nineteenth-century New York, the so-called Astor Place Riot of 10 May 1849, had its unlikely origins in a long-simmering grudge between the two leading Shakespearean actors of the age, William Charles Macready and Edwin ...
Nigel Cliff
doaj +2 more sources
Measuring the star formation rate density from CNOC2 [PDF]
, 2006 This thesis charts the evolution of the Universal Star Formation Rate Density (SFRD) across the redshift range 0.2 < z < 0.6, using the 2nd Canadian Network for Observational Cosmology Survey (CN0C2).
Whitaker, Richard James
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Cambridge Photographic Star Atlas
, 2011 Using the latest methods in digital photography and image processing, The Cambridge Photographic Star Atlas presents the whole sky through large-scale photographic images with corresponding charts. Each double-page spread shows a section of the night sky
Axel Mellinger, Ronald Stoyan
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