Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Probing the Initial Conditions of Clustered Star Formation -- Large Scale On-the-Fly Mapping of Orion B at FCRAO [PDF]
Naomi A. Ridge +2 more
openalex +1 more source
Mapping disease loci to biological processes via joint pleiotropic and epigenomic partitioning. [PDF]
Kerner G +3 more
europepmc +1 more source
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Hα‐derived Star Formation Rates for Threez≃0.75 EDisCS Galaxy Clusters [PDF]
Rose Finn +8 more
openalex +1 more source
Design and Experimental Evaluation of a Hierarchical LoRaMESH-Based Sensor Network with Wi-Fi HaLow Backhaul for Smart Agriculture. [PDF]
Van CC, Tuan AT, Cong DL.
europepmc +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Compact Obscured Star Clusters in the Nearby Starburst Galaxy NGC 253
Ashley Lieber
openalex +1 more source
Recurrent gas accretion by massive star clusters, multiple stellar populations and mass thresholds for spheroidal stellar systems [PDF]
Jan Pflamm-Altenburg, Pavel Kroupa
openalex +1 more source
CLOVER: An analysis protocol for visualization and identification of cell clusters through cluster overlaying for imaging mass cytometry. [PDF]
Kanacharoen S +5 more
europepmc +1 more source

