Results 221 to 230 of about 2,879,280 (414)

A study of stellar population of intermediate-age globular cluster NGC 2249

open access: yesResults in Physics, 2020
The Large Magellanic Cloud (LMC) star cluster NGC 2249 has been found to exhibit an extended main-sequence turn-off (eMSTO) in the color-magnitude diagram (CMD) derived from the data of the Hubble Space Telescope (HST).
Zhongmu Li   +4 more
doaj  

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

open access: yesMolecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song   +13 more
wiley   +1 more source

Phenotypic continuum of NFU1‐related disorders

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022
Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov   +45 more
wiley   +1 more source

Massive Star Cluster Formation with Binaries. I. Evolution of Binary Populations

open access: yesThe Astrophysical Journal
We study the evolution of populations of binary stars within massive cluster-forming regions. We simulate the formation of young massive star clusters within giant molecular clouds with masses ranging from 2 × 10 ^4 to 3.2 × 10 ^5 M _⊙ .
Claude Cournoyer-Cloutier   +9 more
doaj   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

A case of Beauveria bassiana keratitis confirmed by internal transcribed spacer and LSU rDNA D1–D2 sequencing

open access: yesNew Microbes and New Infections, EarlyView., 2014
Abstract We describe a case of fungal keratitis due to Beauveria bassiana in a farmer with Fuchs' dystrophy, treated with amphotericin B. Surgery with penetrating keratoplasty was necessary to resolve the lesions. Susceptibility testing and molecular sequencing permitted the identification and treatment of this rare aetiological agent of invasive ...
M. Ligozzi   +8 more
wiley   +1 more source

Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh   +5 more
wiley   +1 more source

A Young Super Star Cluster Powering a Nebula of Retained Massive Star Ejecta

open access: yesThe Astrophysical Journal
We suggest that “Godzilla” of the lensed Sunburst galaxy ( z = 2.37) is a young super star cluster powering a nebula of gravitationally trapped stellar ejecta.
Massimo Pascale, Liang Dai
doaj   +1 more source

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