Whole-sequence analysis indicates that the Y chromosome C2*-Star Cluster traces back to ordinary Mongols, rather than Genghis Khan. [PDF]
Eur J Hum Genet, 2018 Wei LH +13 more
europepmc +1 more source
UOCS XIV: Study of the Open Cluster NGC 2627 Using UVIT/AstroSat
The Astronomical JournalWe study the intermediate-age open cluster NGC 2627, located at a distance of ∼2 kpc, using UVIT/AstroSat and other archival data. Using a machine learning-based algorithm, ML-MOC, on the Gaia DR3 data, we identify 422 cluster members, including four ...
Pinapati Saketh +2 more
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Electronographic photometry of star clusters in the Magellanic Clouds - VII. The colour-magnitude diagram of NGC 2231 [PDF]
, 1979 Merle F. Walker
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Massive Star Cluster Formation with Binaries. I. Evolution of Binary Populations
The Astrophysical JournalWe study the evolution of populations of binary stars within massive cluster-forming regions. We simulate the formation of young massive star clusters within giant molecular clouds with masses ranging from 2 × 10 ^4 to 3.2 × 10 ^5 M _⊙ .
Claude Cournoyer-Cloutier +9 more
doaj +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
A Young Super Star Cluster Powering a Nebula of Retained Massive Star Ejecta
The Astrophysical JournalWe suggest that “Godzilla” of the lensed Sunburst galaxy ( z = 2.37) is a young super star cluster powering a nebula of gravitationally trapped stellar ejecta.
Massimo Pascale, Liang Dai
doaj +1 more source
The structure of star clusters. IV. Photoelectric surface photometry in nine globular clusters
, 1966 Ivan R. King
openalex +1 more source