Results 251 to 260 of about 440,600 (338)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Cosmic-ray bath in a past supernova gives birth to Earth-like planets. [PDF]

Sci Adv
Sawada R, Kurokawa H, Suwa Y, Taki T, Lee SH, Tanikawa A.   +5 more
europepmc   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

Listening Without the Noise: Near-Silent Looping Star fMRI Reveals Neural Processing of Degraded Speech. [PDF]

Hum Brain Mapp
Ritter CJ, Hüsser AM, Jakab A, Wiesinger F, Solana AB, Fernandez B, Swanborough H, O'Gorman Tuura R, Hervais-Adelman A.   +8 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Single-cell transcriptomics uncovering a critical AKT-LONP1-STAR axis in ovarian hyperandrogenism of PCOS. [PDF]

J Ovarian Res
Zhang C, Lin Z, Lin Y, Ma H.
europepmc   +1 more source

STAR-FORMING BRIGHTEST CLUSTER GALAXIES AT 0.25 < z < 1.25: A TRANSITIONING FUEL SUPPLY

, 2017
B. Stalder, Matthew Bayliss, S. W. Allen, Douglas Applegate, M. L. N. Ashby, B. A. Benson, L. E. Bleem, M. Brodwin, J. E. Carlstrom, I-Non Chiu, S. Desai, Anthony H. Gonzalez, Julie Hlavacek-Larrondo, W. L. Holzapfel, Daniel P. Marrone, Eric D. Miller, C. L. Reichardt, B. R. Saliwanchik, A. Saro, T. Schrabback, S. A. Stanford, A. A. Stark, J. D. Vieira, A. Zenteno, McDonald, Michael A., Bautz, Marshall W.   +25 more
openalex   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Protocol for rapid allelic discrimination qPCR genotyping of the Winnie mouse model. [PDF]

STAR Protoc
Mansoori B, Liang C.
europepmc   +1 more source