Results 271 to 280 of about 2,684,722 (398)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Protocol for assembling, prioritizing, and characterizing piRNA clusters using the piRNA Cluster Builder. [PDF]

STAR Protoc
Ahrend F, Konstantinidou P, Loubalova Z, Wang Y, Lorenzi H, Meister G, Haase AD.   +6 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Hyperspectral reflectance imaging and spectral component analysis techniques to reveal distinct color patterns on plant leaves. [PDF]

STAR Protoc
Krishnamoorthi S, Urano D.
europepmc   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Earth-mass planets with He atmospheres in the habitable zone of Sun-like stars. [PDF]

Nat Astron
Lammer H, Scherf M, Erkaev NV, Kubyshkina D, Gorbunova KD, Fossati L, Woitke P.   +6 more
europepmc   +1 more source

Light element abundance inhomogeneities in globular clusters: probing star formation and evolution in the early Milky Way [PDF]

, 1994
Michael M. Briley, R. A. Bell, J. E. Hesser, Graeme H. Smith   +3 more
openalex   +1 more source

Extreme magnification of an individual star at redshift 1.5 by a galaxy-cluster lens

Nature Astronomy, 2018
P. Kelly, J. Diego, S. Rodney, N. Kaiser, T. Broadhurst, A. Zitrin, T. Treu, P. Pérez-González, T. Morishita, M. Jauzac, J. Selsing, M. Oguri, L. Pueyo, Timothy Ross, A. Filippenko, N. Smith, J. Hjorth, S. Cenko, Xin Wang, D. Howell, J. Richard, B. Frye, S. Jha, R. Foley, C. Norman, M. Bradač, Weikang Zheng, G. Brammer, A. Benito, A. Cava, L. Christensen, S. D. de Mink, O. Graur, C. Grillo, R. Kawamata, J. Kneib, T. Matheson, C. McCully, M. Nonino, I. Pérez-Fournon, A. Riess, P. Rosati, K. Schmidt, K. Sharon, B. Weiner   +44 more
semanticscholar   +1 more source

A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma

Molecular Oncology, EarlyView.
Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley   +1 more source

A left-lateralized dorsolateral prefrontal network for naming. [PDF]

Cell Rep
Yu L, Dugan P, Doyle W, Devinsky O, Friedman D, Flinker A.   +5 more
europepmc   +1 more source