Results 141 to 150 of about 2,681,556 (391)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Revisiting Open Clusters within 200 pc in the Solar Neighborhood with Gaia DR3

The Astronomical Journal
In this study, we develop a membership identification method and apply it for 30 open clusters (OCs) within 200 pc of the Sun using astrometric data of Gaia DR3.
Penghui Liu, Min Fang, Yue-Lin Sming Tsai, Xiaoying Pang, Fan Wang, Xiaoting Fu   +5 more
doaj   +1 more source

The influence of residual gas expulsion on the evolution of the Galactic globular cluster system and the origin of the Population II halo

, 2007
We present new results on the evolution of the mass function of the globular cluster system of the Milky Way, taking the effect of residual gas expulsion into account.
Bastian, Baumgardt, Baumgardt, Baumgardt, Baumgardt, Baumgardt, Binney, Boily, Boily, Boutloukos, Chaboyer, Chandar, Chiba, D'Antona, Dabringhausen, de Grijs, de la Fuente Marcos, Decressin, Decressin, Engargiola, Evstigneeva, Fall, Fall, Freeman, Freyer, Freyer, G. Parmentier, Gieles, Gieles, Gnedin, Goodwin, Gratton, Gratton, Gratton, H. Baumgardt, Harris, Harris, Harris, Hilker, Hills, Innanen, Jórdan, Kavelaars, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kundu, Kundu, Lada, Lamers, Larsen, Larsen, Mackey, McLaughlin, Meylan, Nantais, Okazaki, Ostriker, P. Kroupa, Parmentier, Parmentier, Parmentier, Piotto, Prantzos, Rosolowsky, Secker, Sneden, Solomon, Spitzer, Tamura, Tremaine, van den Bergh, van den Bergh, VandenBerg, Verschueren, Vesperini, Vesperini, Vesperini, Vesperini, Vesperini, Weidner, Weidner, Whitmore, Whitmore, Whitmore, Zhang, Zinn   +90 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

VLA 22 GHz Imaging of Massive Star Formation in Local Wolf–Rayet Galaxies

The Astrophysical Journal
We present 22 GHz imaging of regions of massive star formation within the Local Wolf–Rayet Galaxy Sample, a NSF Karl G. Jansky Very Large Array survey of 30 local galaxies showing spectral features of Wolf–Rayet (WR) stars.
Nicholas G. Ferraro, Jean L. Turner, Sara C. Beck, Edwin Alexani, Runa Indrei, Bethany M. Welch, Tunhui Xie   +6 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Forest Fire Clustering: A Novel Tool for Identifying Star Members of Clusters

The Astronomical Journal
In the era of a data-driven landscape, the development of an efficient and interpretable method has become a pivotal tool for robustly identifying memberships of clusters.
Xingyin Wei, Jing Chen, Su Zhang, Feilong He, Yunbo Zhao, Xuran He, Yongjie Fang, Xinhao Chen, Hao Yang   +8 more
doaj   +1 more source

Families of dynamically hot stellar systems over ten orders of magnitude in mass

, 2011
Dynamically hot stellar systems, whether star clusters or early-type galaxies, follow well-defined scaling relations over many orders of magnitudes in mass.
Bekki, Bekki, Belokurov, Belokurov, Belokurov, Bender, Bender, Bernardi, Binney, Blakeslee, Brosche, Bruzual, Burstein, Böker, Capuzzo-Dolcetta, Chilingarian, Chilingarian, Chilingarian, Cimatti, Collins, Côté, Côté, Dabringhausen, Damjanov, de Jong, Dirsch, Djorgovski, Drinkwater, Evstigneeva, Faber, Faber, Fellhauer, Ferrarese, Forbes, Fukugita, Gieles, Gilmore, Graham, Graham, Grebel, Hilker, Hopkins, Hopkins, I. Misgeld, Irwin, Jordi, Jordán, Kalirai, Kissler-Patig, Koposov, Kormendy, Kormendy, Kormendy, Kroupa, Kroupa, Kroupa, M. Hilker, Mancini, Maraston, Maraston, Martin, Martin, Mateo, McConnachie, McConnachie, McLaughlin, Mei, Mieske, Mieske, Mieske, Mieske, Milgrom, Misgeld, Misgeld, Murray, Naab, Newman, Niederste-Ostholt, Paturel, Paudel, Paudel, Peng, Pflamm-Altenburg, Price, Rossa, Smith Castelli, Smith Castelli, Tiret, Tollerud, van Dokkum, Walcher, Zaritsky, Zaritsky, Zaritsky, Łokas   +94 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Gamma Rays from Star Formation in Clusters of Galaxies

, 2012
Star formation in galaxies is observed to be associated with gamma-ray emission. The detection of gamma rays from star-forming galaxies by the Fermi Large Area Telescope (LAT) has allowed the determination of a functional relationship between star ...
Abdo, Ackermann, Ackermann, Bai, Book, Chung, Chung, Clarke, Dale, Egami, Emma M. Storm, Han, McDonald, Miller, Reddy, Reiprich, Rieke, Stefano Profumo, Tesla E. Jeltema, Voelk, Yun   +20 more
core   +1 more source