Results 141 to 150 of about 71,711 (296)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

New Parameters for Star Cluster Dynamics: The Role of Clusters’ Initial Conditions

The Astrophysical Journal
We recently introduced three new parameters that describe the shape of the normalized cumulative radial distribution (nCRD) of the innermost stars in globular clusters (GCs) and trace the clusters’ dynamical evolution.
B. Bhat, B. Lanzoni, E. Vesperini, F. R. Ferraro, F. I. Aros, A. Askar, A. Hypki   +6 more
doaj   +1 more source

Probable OB Star Members in Eleven Berkeley Clusters [PDF]

, 1974
N. Sanduleak
openalex   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Identification of Star Clusters in M31 from PAndAS Images Based on Deep Learning

The Astrophysical Journal Supplement Series
The identification of star clusters holds significant importance in studying galaxy formation and evolution history. However, the task of swiftly and accurately identifying star clusters from vast amounts of photometric images presents an immense ...
Baisong Zhang, Bingqiu Chen, Haibo Yuan, Pinjian Chen, Shoucheng Wang, Lunwei Zhang, Yi Ren, Helong Guo   +7 more
doaj   +1 more source

Commission 37: Star Clusters and Associations [PDF]

, 1971

openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

The Stellar Initial Mass Function of Early Dark Matter–free Gas Objects

The Astrophysical Journal Letters
Among the remarkable strides made by JWST is the discovery of the earliest star clusters found to date. These have been proposed as early progenitors of globular clusters, which are known to come from the early stages of star formation in the Universe ...
William Lake, Michael Y. Grudić, Smadar Naoz, Naoki Yoshida, Claire E. Williams, Blakesley Burkhart, Federico Marinacci, Mark Vogelsberger, Avi Chen   +8 more
doaj   +1 more source

The Structure of Star Clusters. V. Star Counts in 54 Globular Clusters

, 1968
Ivan R. King, Jr. Hedemann Edmund, Steven Hodge, Raymond E. White   +3 more
openalex   +1 more source