Results 151 to 160 of about 2,681,556 (391)

The mass function of young star clusters in spiral galaxies [PDF]

, 2008
S. S. Larsen
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Near-infrared Spectral Library of Very Young Brown Dwarfs and Planetary Mass Objects in the Orion Nebula Cluster

The Astrophysical Journal
Age-benchmark brown dwarf and planetary-mass-object spectroscopy is key to characterizing substellar evolution. In this paper, we present the JHK medium-resolution ( R ∼ 3000) spectra of 25 7–76 M _Jup (spectral types L3.0–M6.0) brown dwarfs and ...
Elena Manjavacas, Mario Gennaro, Sarah Betti, Laurent Pueyo, William O. Balmer, Massimo Robberto   +5 more
doaj   +1 more source

VLA and ATCA Search for Natal Star Clusters in Nearby Star-Forming Galaxies

, 2011
In order to investigate the relationship between the local environment and the properties of natal star clusters, we obtained radio observations of 25 star-forming galaxies within 20 Mpc using the Very Large Array (VLA) and the Australia Telescope ...
Aversa, Alan, Brogan, Crystal, Goss, W., Johnson, Kelsey, Pisano, D. J.   +4 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The Impact of Stellar Radiative Feedback on Formation of Young Massive Clusters via Fast H i Gas Collisions

The Astrophysical Journal
Young massive clusters (YMCs) are dense aggregates of young stars and are often speculated as potential precursors to globular clusters. However, the formation mechanism of massive and compact gas clumps that precede YMCs remains unknown.
Ryunosuke Maeda, Tsuyoshi Inoue, Kazuyuki Omukai, Yasuo Fukui, Kisetsu Tsuge   +4 more
doaj   +1 more source

On the efficiency of field star capture by star clusters

, 2007
An exciting recent finding regarding scaling relations among globular clusters is the so-called 'blue tilt': clusters of the blue sub-population follow a trend of redder colour with increasing luminosity.
Baranov, Baumgardt, Bedin, Bekki, Bekki, Côté, D'Antona, de Oliveira Filho, Dopita, Fellhauer, Frank, Gnedin, H. Baumgardt, Harris, Jordán, Jordán, Lamers, Mieske, Mints, Morgan, Parmentier, Parmentier, Peng, Piotto, Prantzos, Recchi, Romanowsky, S. Mieske, Smith, Spitler, Strader, Thoul   +31 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Revisit of 77 Clusters Candidates with Multiple Main Sequences using Gaia DR3

The Astronomical Journal
Gaia DR3 data provide the latest and full astrometric data for more than 1.5 billion sources, and these allow us to revisit the 77 special open cluster candidates collected from LISC star cluster catalog.
Jing Chen, Zhongmu Li, Su Zhang, Wenchang Zhao, You Wu   +4 more
doaj   +1 more source

Globular Cluster Formation in M82

, 2003
We present high resolution mid-infrared (mid-IR; 11.7 and 17.65 micron) maps of the central 400 pc region of the starburst galaxy M82. Seven star forming clusters are identified which together provide ~ 15% of the total mid-IR luminosity of the galaxy ...
Cottrell G., Knodlseder J., Mandushev G., Neininger N., P. Plavchan, S. J. Lipscy, Weliachew L.   +6 more
core   +2 more sources