Results 161 to 170 of about 2,622,417 (397)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

VLA 22 GHz Imaging of Massive Star Formation in Local Wolf–Rayet Galaxies

The Astrophysical Journal
We present 22 GHz imaging of regions of massive star formation within the Local Wolf–Rayet Galaxy Sample, a NSF Karl G. Jansky Very Large Array survey of 30 local galaxies showing spectral features of Wolf–Rayet (WR) stars.
Nicholas G. Ferraro, Jean L. Turner, Sara C. Beck, Edwin Alexani, Runa Indrei, Bethany M. Welch, Tunhui Xie   +6 more
doaj   +1 more source

Families of dynamically hot stellar systems over ten orders of magnitude in mass

, 2011
Dynamically hot stellar systems, whether star clusters or early-type galaxies, follow well-defined scaling relations over many orders of magnitudes in mass.
Bekki, Bekki, Belokurov, Belokurov, Belokurov, Bender, Bender, Bernardi, Binney, Blakeslee, Brosche, Bruzual, Burstein, Böker, Capuzzo-Dolcetta, Chilingarian, Chilingarian, Chilingarian, Cimatti, Collins, Côté, Côté, Dabringhausen, Damjanov, de Jong, Dirsch, Djorgovski, Drinkwater, Evstigneeva, Faber, Faber, Fellhauer, Ferrarese, Forbes, Fukugita, Gieles, Gilmore, Graham, Graham, Grebel, Hilker, Hopkins, Hopkins, I. Misgeld, Irwin, Jordi, Jordán, Kalirai, Kissler-Patig, Koposov, Kormendy, Kormendy, Kormendy, Kroupa, Kroupa, Kroupa, M. Hilker, Mancini, Maraston, Maraston, Martin, Martin, Mateo, McConnachie, McConnachie, McLaughlin, Mei, Mieske, Mieske, Mieske, Mieske, Milgrom, Misgeld, Misgeld, Murray, Naab, Newman, Niederste-Ostholt, Paturel, Paudel, Paudel, Peng, Pflamm-Altenburg, Price, Rossa, Smith Castelli, Smith Castelli, Tiret, Tollerud, van Dokkum, Walcher, Zaritsky, Zaritsky, Zaritsky, Łokas   +94 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Forest Fire Clustering: A Novel Tool for Identifying Star Members of Clusters

The Astronomical Journal
In the era of a data-driven landscape, the development of an efficient and interpretable method has become a pivotal tool for robustly identifying memberships of clusters.
Xingyin Wei, Jing Chen, Su Zhang, Feilong He, Yunbo Zhao, Xuran He, Yongjie Fang, Xinhao Chen, Hao Yang   +8 more
doaj   +1 more source

The influence of residual gas expulsion on the evolution of the Galactic globular cluster system and the origin of the Population II halo

, 2007
We present new results on the evolution of the mass function of the globular cluster system of the Milky Way, taking the effect of residual gas expulsion into account.
Bastian, Baumgardt, Baumgardt, Baumgardt, Baumgardt, Baumgardt, Binney, Boily, Boily, Boutloukos, Chaboyer, Chandar, Chiba, D'Antona, Dabringhausen, de Grijs, de la Fuente Marcos, Decressin, Decressin, Engargiola, Evstigneeva, Fall, Fall, Freeman, Freyer, Freyer, G. Parmentier, Gieles, Gieles, Gnedin, Goodwin, Gratton, Gratton, Gratton, H. Baumgardt, Harris, Harris, Harris, Hilker, Hills, Innanen, Jórdan, Kavelaars, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kundu, Kundu, Lada, Lamers, Larsen, Larsen, Mackey, McLaughlin, Meylan, Nantais, Okazaki, Ostriker, P. Kroupa, Parmentier, Parmentier, Parmentier, Piotto, Prantzos, Rosolowsky, Secker, Sneden, Solomon, Spitzer, Tamura, Tremaine, van den Bergh, van den Bergh, VandenBerg, Verschueren, Vesperini, Vesperini, Vesperini, Vesperini, Vesperini, Weidner, Weidner, Whitmore, Whitmore, Whitmore, Zhang, Zinn   +90 more
core   +1 more source

Star clusters in evolving galaxies [PDF]

New Astronomy Reviews, 2018
Their ubiquity and extreme densities make star clusters probes of prime importance of galaxy evolution. Old globular clusters keep imprints of the physical conditions of their assembly in the early Universe, and younger stellar objects, observationally resolved, tell us about the mechanisms at stake in their formation.
openaire   +4 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Massive Star Formation in Luminous Infrared Galaxies: Giant HII Regions and their relation to Super Star Clusters

, 2002
We have used HST/NICMOS H-band narrow-band Pa-alpha (at rest 1.87micron) images to identify star clusters and HII regions respectively in a sample of 8 luminous infrared galaxies (LIRGs).
Almudena Alonso-Herrero, George H. Rieke, Marcia J. Rieke, Nick Z. Scoville, Pleuss P. O.   +4 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source