Results 241 to 250 of about 5,183,495 (311)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Feedback mechanisms stopping the star formation in a pair of massive galaxies in the early Universe

Pérez-González P, D'Eugenio F, Pino BRD, Perna M, Uebler H, Maiolino R, Arribas S, Lamperti I, Bunker A, Carniani S, Charlot S, Willott C, Böker T, Parlanti E, Scholtz J, Venturi G, Barro G, Costantin L, Navarro IM, Dunlop J, Magee D, Cresci G.   +21 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Two-Year Bonding Performances of a Universal Adhesive After Dentin Pre-Treatment With Two-Step Silver-Containing Solutions. [PDF]

J Adhes Dent
D'Alessandro C, Josic U, Maravic T, D'Urso D, Checchi V, Mazzoni A, Breschi L, Mazzitelli C.   +7 more
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Extreme properties of a compact and massive accreting black hole host in the first 500 Myr. [PDF]

Nat Commun
Tripodi R, Martis N, Markov V, Bradač M, Di Mascia F, Cammelli V, D'Eugenio F, Willott C, Curti M, Bhatt M, Gallerani S, Rihtaršič G, Singh J, Gaspar G, Harshan A, Judež J, Merida RM, Desprez G, Sawicki M, Goovaerts I, Muzzin A, Noirot G, Sarrouh GTE, Abraham R, Asada Y, Brammer G, Estrada-Carpenter V, Felicioni G, Fujimoto S, Iyer K, Mowla L, Strait V.   +31 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Evolutionary characteristics and driving factors of innovative cooperation networks in the field of CCUS technology in China. [PDF]

Sci Rep
Zhao Z, Cui Y.
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Chain ends excite polymer cooperative motion. [PDF]

Sci Adv
Xu Q, Wu Z, Randazzo K, Xu WS, Zhang B, Priestley RD, Zuo B.   +6 more
europepmc   +1 more source