We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová+14 more
wiley +1 more source
Predicting organoid morphology through a phase field model: Insights into cell division and lumenal pressure. [PDF]
Tanida S+10 more
europepmc +1 more source
An IUE search for star formation in ellipticals with gaseous disks
F. Bertola+3 more
openalex +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy+9 more
wiley +1 more source
Histologic evaluation of furcation perforation treated using bioceramic putty with and without platelet rich fibrin or chitosan hydrogel as an internal matrix. [PDF]
Anwar Laithy MS+4 more
europepmc +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster+3 more
wiley +1 more source
The evolution of ABC star polymers: from trial-and-error to rational design. [PDF]
Kalina M, Nouri B, Almdal K.
europepmc +1 more source
Explosive ejection of matter associated with star formation in the Orion nebula
D. A. Allen, Michael Burton
openalex +1 more source
Tumor‐associated bacteria (TAB) dynamically influence cancer biology by modulating tumor progression, metastatic spread, and therapeutic efficacy. Their presence redefines the tumor microenvironment (TME) as a microbial–host interface, yet mechanistic insights remain limited. Understanding TAB colonization routes, functional impacts, and crosstalk with
Gerlanda Vella, Maria Rescigno
wiley +1 more source
Synthesis of Highly Ordered Amphiphilic Polymer Conetwork Hydrogels via the Topologically Precise Interconnection of Two Highly Incompatible Polymers. [PDF]
Apostolides DE+11 more
europepmc +1 more source