Results 171 to 180 of about 636,610 (341)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

From UV-bright Galaxies to Early Disks: The Importance of Turbulent Star Formation in the Early Universe

The Astrophysical Journal
Bursty star formation at early times can explain the surprising abundance of early UV-bright galaxies revealed by JWST but can also be a reason for the delayed formation of galactic disks in high-resolution cosmological simulations.
Vadim A. Semenov, Charlie Conroy, Lars Hernquist   +2 more
doaj   +1 more source

Cosmic Star Formation Rate From Gamma-Ray Attenuation

, 1999
T. Kneiske, K. Mannheim
openalex   +2 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Limits on the star formation rates of z>2 damped Ly-alpha systems from H-alpha spectroscopy

, 1998
Andrew J. Bunker, S. J. Warren, D. L. Clements, G. M. Williger, P. C. Hewett   +4 more
openalex   +2 more sources

Constraining the cosmic star formation rate with the MeV backgroung [PDF]

, 2003
K. Watanabe, D. H. Hartmann, M. D. Leising, Lih‐Sin The   +3 more
openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

The Critical Role of Dark Matter Halos in Driving Star Formation

The Astrophysical Journal Letters
Understanding the physical mechanisms that drive star formation is crucial for advancing our knowledge of galaxy evolution. We explore the interrelationships between key galaxy properties associated with star formation, with a particular focus on the ...
Jing Dou, Yingjie Peng, Qiusheng Gu, Luis C. Ho, Alvio Renzini, Yong Shi, Emanuele Daddi, Dingyi Zhao, Chengpeng Zhang, Zeyu Gao, Di Li, Cheqiu Lyu, Filippo Mannucci, Roberto Maiolino, Tao Wang, Feng Yuan   +15 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

UV star-formation rates of GRB host galaxies [PDF]

, 2004
L. Christensen, J. Hjorth, J. Gorosabel
openalex   +1 more source