Results 191 to 200 of about 1,223,277 (388)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Quantification of the Age Dependence of Mid-infrared Star Formation Rate Indicators

open access: yesThe Astrophysical Journal
We combine James Webb Space Telescope images of the nearby galaxy NGC 5194 in the hydrogen recombination line Pa α (1.8756 μ m) from the Cycle 1 program JWST-FEAST with 21 μ m dust continuum images from the Cycle 2 Treasury program JWGT to quantify the ...
Daniela Calzetti   +35 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Why is the Star Formation Rate Proportional to Dense Gas Mass?

open access: yesThe Astrophysical Journal
One of the most profound empirical laws of star formation is the Gao–Solomon relation, a linear correlation between the star formation rate (SFR) and the dense molecular gas mass.
Sihan Jiao   +16 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Star Formation in the Lopsided Galaxy Arp 291

open access: yesThe Astrophysical Journal
We have investigated the star formation process taking place in the lopsided galaxy Arp 291, based on narrowband images in the H α , [N ii ] λ 6583, and [O iii ] λ 5007 emission lines, obtained using the modern tunable photometer MaNGaL at the Caucasus ...
Irina S. Proshina, Dmitriy V. Oparin
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

MAUVE-MUSE: A Star-formation-driven Outflow Caught in the Act of Quenching the Stripped Virgo Galaxy NGC 4064

open access: yesThe Astrophysical Journal Letters
The rapid quenching of satellite galaxies in dense environments is often attributed to environmental processes such as ram pressure stripping. However, stripping alone cannot fully account for the removal of dense, star-forming gas in many satellites ...
Amy Attwater   +12 more
doaj   +1 more source

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