Results 211 to 220 of about 1,223,277 (388)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The ALMaQUEST Survey. XIII. Understanding Radial Trends in Star Formation Quenching via the Relative Roles of Gas Availability and Star Formation Efficiency

The Astrophysical Journal
Star formation quenching is one of the key processes that shape the evolution of galaxies. In this study, we investigate the changes in molecular gas and star formation properties as galaxies transit from the star-forming main sequence to the passive ...
Hsi-An Pan, Lihwai Lin, Sara L. Ellison, Mallory D. Thorp, Sebastián F. Sánchez, Asa F. L. Bluck, Francesco Belfiore, Joanna M. Piotrowska, Jillian M. Scudder, William M. Baker   +9 more
doaj   +1 more source

Dependence of Star Formation Rate on Overdensity [PDF]

, 1999
Kentaro Nagamine, Renyue Cen, Jeremiah P. Ostriker   +2 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The Evolution of Molecular Clouds: Turbulence-regulated Global Radial Collapse

The Astrophysical Journal
The star formation efficiency (SFE) measures the proportion of molecular gas converted into stars, while the star formation rate (SFR) indicates the rate at which gas is transformed into stars.
An-Xu Luo, Hong-Li Liu, Jin-Zeng Li
doaj   +1 more source

Far-infrared And Nebular Star-formation Rates Of Dusty Star Forming\n Galaxies From Herschel And 3d-hst At Z~1 [PDF]

, 2018
Farhanul Hasan, Hooshang Nayyeri, Asantha C. Cooray   +2 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Isolated and group environment dependence of stellar mass and different star formation rates [PDF]

Pius Privatus, Umananda Dev Goswami
openalex   +1 more source

Cii* Absorption in Damped Lyα Systems. I. Star Formation Rates in a Two‐Phase Medium [PDF]

, 2003
Arthur M. Wolfe, J. X. Prochaska, Eric Gawiser   +2 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source