Results 251 to 260 of about 636,610 (341)

In vitro, genomic characterization and pre-clinical evaluation of a new thermostable lytic Obolenskvirus phage formulated as a hydrogel against carbapenem-resistant Acinetobacter baumannii. [PDF]

Sci Rep
Sherif MM, Abdelaziz NA, Alshahrani MY, Saleh SE, Aboshanab KM.   +4 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A nearby dark molecular cloud in the Local Bubble revealed via H₂ fluorescence. [PDF]

Nat Astron
Burkhart B, Dharmawardena TE, Bialy S, Haworth TJ, Cruz Aguirre F, Jo YS, Andersson BG, Chung H, Edelstein J, Grenier I, Hamden ET, Han W, Hoadley K, Lee MY, Min KW, Müller T, Pattle K, Peek JEG, Pleiss G, Schiminovich D, Seon KI, Wilson AG, Zucker C.   +22 more
europepmc   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Luminosity Functions and Star Formation Rates at z~6-10: Galaxy Buildup in the Reionization Age

, 2005
R. J. Bouwens, G. D. Illingworth
openalex   +2 more sources

Protocol for dorsal ovariectomy and elastase-induced abdominal aortic aneurysm in rats. [PDF]

STAR Protoc
Zaghloul MS, Elizondo-Benedetto S, Alrata L, Ibrahim D, Speller N, Koklu B, Arif B, Zayed MA.   +7 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

The cosmic star formation rate evolution from z=5 to z=0 from the VIMOS VLT Deep Survey

, 2006
L. Tresse, O. Ilbert, E. Zucca, G. Zamorani, S. Bardelli, S. Arnouts, S. Paltani, L. Pozzetti, D. Bottini, B. Garilli, V. Le Brun, O. Le Fèvre, D. Maccagni, J. P. Picat, R. Scaramella, M. Scodeggio, G. Vettolani, A. Zanichelli, C. Adami, M. Arnaboldi, M. Bolzonella, A. Cappi, Stéphane Charlot, P. Ciliegi, T. Contini, S. Foucaud, P. Franzetti, I. Gavignaud, L. Guzzo, A. Iovino, H. J. McCracken, B. Marano, C. Marinoni, A. Mazure, B. Meneux, R. Merighi, R. Pelló, A. Pollo, M. Radovich, M. Bondi, A. Bongiorno, G. Busarello, O. Cucciati, Fabrice Lamareille, G. Mathez, Y. Mellier, P. Merluzzi, V. Ripepi   +47 more
openalex   +2 more sources

Hydrophilic and Amphiphilic Macromolecules as Modulators of the Physical Stability and Bioavailability of Piribedil: A Study on Binary Mixtures and Micellar Systems. [PDF]

Mol Pharm
Orszulak L, Minecka A, Bernat R, Lamrani T, Jurkiewicz K, Hachuła B, Tarnacka M, Geppert-Rybczyńska M, Zubko M, Staniszewska M, Smoleński M, Dobosz J, Garbacz G, Kamiński K, Kamińska E.   +14 more
europepmc   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source