Results 181 to 190 of about 3,871,291 (295)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Identifying the principal mechanism of star formation feedback. [PDF]

Sci Adv
Li C, Li R, Qiu K, Krco M, Li D, Wang H, Lyu X, Duan Y, Fang M, Chen X, Wang L, Feng H, Zhang S, Zhang M, Zhang S, Cao Y, Wang Y, Gong Y, Du F, Chen Z, Su Y, Ma Y, Xing Y, Zheng Y, Zhang T, Niu S, Li C, Liu J, Zhang Z, Guo Y.   +29 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Red novae, their progenitors, and remnants. [PDF]

Astron Astrophys Rev
Kamiński T, Blagorodnova N.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Numerous bow shocks in the outer Helix Nebula. [PDF]

Nature
van Dokkum P, Abraham R, Bowman WP, Chen S, Janssens SR, Lokhorst DM, Pasha I, Rhea C.   +7 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

An Agent-Based Model of the Stellar Mass Distribution. [PDF]

Entropy (Basel)
Olguín-Rodríguez ER, Gershenson C, Vázquez-Semadeni E.   +2 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Rapid quasi-periodic reconfiguration of the accretion column in pulsar 1A 0535+262. [PDF]

Nat Commun
Kong L, Dai X, Santangelo A, Ji L, Suleimanov VF, Mushtukov AA, Ducci L, Zhang S, Shui Q, Zhang SN, Feng H, Tsygankov SS, Liu H, Wang P, Liu Q.   +14 more
europepmc   +1 more source