Results 241 to 250 of about 3,871,291 (295)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Detection, characterization, and evolutionary inferences regarding a novel virus identified in Amblyomma dissimile Koch, 1844 (Acari: Ixodidae) from the Amazon, Pará, Brazil. [PDF]

Arch Virol
da Silva E Silva LH, da Silva SP, de Castro PHG, Maurício KD, da Silva FS, Dias DD, Hernández LHA, da Silva SLS, Reis HCF, Dos Santos LEC, do Nascimento BLS, Brandão RCF, Vieira DBR, Nunes BTD, Cruz ACR, Nunes Neto JP.   +15 more
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Etching characteristics and profile simulation of silicon. [PDF]

PLoS One
Zhang H, Cai P.
europepmc   +1 more source

Entropy Production During Star Formation: An Analytic Thermodynamic Framework from the Main Sequence to Compact Remnants. [PDF]

Entropy (Basel)
Martín-Torres J, Zorzano MP.
europepmc   +1 more source

Carbon reduction multidimensional ternary model for robotic 3D printing prefabricated construction across hotels star levels. [PDF]

Carbon Balance Manag
Cai G, Guo X, Chen J, Wu Q, Pan Y, Yao Y, Lu Y, Sun Y, Lu F, Gao W.   +9 more
europepmc   +1 more source

Super-Critical Accretion onto Stellar Mass Black Holes and Neutron Stars: A Short Review. [PDF]

Space Sci Rev
Middleton M, Lipunova G, Ohsuga K, Abramowicz M.   +3 more
europepmc   +1 more source

A compact set of sea star footprint proteins is mediating the adhesion of Asterina gibbosa

Lengerer B, Bertemes P, Szucs A, Ladurner P, Mertens B, Grosbusch A, Wattiez R, Flammang P.   +7 more
europepmc   +1 more source