Results 111 to 120 of about 412,361 (248)

Ruthenium‐Catalyzed Azide‐Selenoalkyne Cycloadditions: A Combined Synthetic–Computational Study into Reaction Scope, Mechanism, and Origins of Regioselectivity

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
A ruthenium‐catalyzed azide–alkyne cycloaddition (RuAAC) reaction is reported for the synthesis of selenium‐substituted triazole products. Reaction regioselectivity is dependent on the identity of the non‐selenium substituent of the alkyne, which challenges the perceived understanding of RuAAC regioselectivity.
Frances E. Bugden   +9 more
wiley   +1 more source

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

open access: yesAdvanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong   +16 more
wiley   +1 more source

Oral Celastrol Micelles Forming High‐Density Lipoprotein Corona Targeting Hepatocytes for MASLD Treatment

open access: yesAdvanced Science, EarlyView.
Upon oral administration, OPDEA‐PCL/CEL micelles passed through the stomach acid intact, then quickly penetrated the intestinal mucus and transported into circulation, where they captured HDL to form a protein corona and target hepatocyte SR‐B1 receptors, inducing endocytosis.
Chang Xu   +11 more
wiley   +1 more source

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

open access: yesAdvanced Science, EarlyView.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source

Evolution of competitive systems in nature. [PDF]

open access: yesSci Rep
Deng C   +7 more
europepmc   +1 more source

Modeling Control of Invasive Fire Ants by Gene Drive

open access: yesAdvanced Science, EarlyView.
The fire ant Solenopsis invicta is characterized by exceptional invasive capabilities, rendering conventional control ineffective. Here, we explore the use of homing suppression gene drive in fire ants by developing a spatially explicit model. Overall, these results show that target population suppression requires an extended time scale, but that gene ...
Yiran Liu   +3 more
wiley   +1 more source

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