Results 121 to 130 of about 1,211,714 (251)

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

Adaptive Deployable Structure Enabled by Actively Controlled Tensegrity for Space Debris Removal

Advanced Science, EarlyView.
An innovative adaptive deployable structure leveraging tensegrity principles to capture and remove medium‐ and small‐sized space debris. The structure's active rope control ensures stability across various positions, enabling adaptive deformation. This design not only addresses space debris removal but also supports advancements in deployable antennas ...
Endong Shang, Ao Li, Md Shariful Islam, Li‐Yuan Zhang, Changyong (Chase) Cao   +4 more
wiley   +1 more source

Epithelial Cell Mechanoresponse to Matrix Viscoelasticity and Confinement Within Micropatterned Viscoelastic Hydrogels

Advanced Science, EarlyView.
Extracellular matrix (ECM) viscoelasticity and spatial confinement regulate cellular processes such as cancer progression, yet their interplay remains poorly understood. By developing fibronectin (FN)‐micropatterned viscoelastic hydrogels mimicking breast cancer mechanics, this study explores breast epithelial cell mechanoresponse to ECM ...
Giuseppe Ciccone, Mariana Azevedo Gonzalez‐Oliva, Marie Versaevel, Marco Cantini, Massimo Vassalli, Manuel Salmeron‐Sanchez, Sylvain Gabriele   +6 more
wiley   +1 more source

TIA1‐Mediated Stress Granules Promote the Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis through Upregulating IL‐31RA Signaling

Advanced Science, EarlyView.
In EAE mice, TIA1 is translocated from the nucleus to the cytoplasm, facilitating SGs formation in neurons. TIA1 knockout in the central nervous system (CNS) of EAE mice yields a notable diminution in neuronal SGs, mitigates CNS inflammatory infiltration, and curtails axonal demyelination.
Xin Hua, Lingting Jin, Zheyu Fang, Yiyun Weng, Yuan Zhang, Jingjing Zhang, Dewei Xie, Yang Tang, Siyu Guo, Yingying Huang, Yilin Dai, Jia Li, Zhihui Huang, Xu Zhang   +13 more
wiley   +1 more source

ROS‐Responsive Microneedle Patches Enable Peri‐Lacrimal Gland Therapeutic Administration for Long‐Acting Therapy of Sjögren's Syndrome‐Related Dry Eye

Advanced Science, EarlyView.
A new strategy for constructing smart gel‐based MN patches is developed to overcome the insufficient drug delivery of eye drops to the lacrimal gland. The gel‐based MN patches achieved long‐acting drug release in a ROS‐responsive manner, and separable base in a temperature‐responsive manner.
Jingqing Mu, Xiangyu Ding, Yapeng Song, Baoyue Mi, Xiaolong Fang, Baihua Chen, Bin Yao, Xuguang Sun, Xiaoyong Yuan, Shutao Guo, Xia Hua   +10 more
wiley   +1 more source

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

Modular Calcium‐Responsive and CD9‐Targeted Phospholipase System Enhancing Endosomal Escape for DNA Delivery

Advanced Science, EarlyView.
A modular endosomal escape system boosts transfection efficiency of a DNA delivery agent. This system comprises a phospholipase fused to a split‐calbindin domain and a nanobody targeting CD9. In the extracellular space, the phospholipase is tightly bound to protein‐DNA complexes, released within endosomes at low calcium concentrations and recruited to ...
Alexander Klipp, Christina Greitens, David Scherer, Alexander Elsener, Jean‐Christophe Leroux, Michael Burger   +5 more
wiley   +1 more source

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models

Advanced Science, EarlyView.
This study uncovers that stress granules (SGs) are involved in the pathogenesis of Parkinson's disease (PD). Perillaldehyde (PAE) can improve Parkinson‐like deficits in preclinical models by directly binding to G3BP and instigating liquid–liquid phase separation (LLPS) of G3BP.
Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan   +12 more
wiley   +1 more source

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Advanced Science, EarlyView.
Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Jun Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Haizhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, Xue‐Min Zhang, Ai‐Ling Li, Xin Pan   +17 more
wiley   +1 more source