Results 141 to 150 of about 412,361 (248)

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

open access: yesAdvanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng   +15 more
wiley   +1 more source

Lignin‐Containing Nanocellulose Mediated Interlayer Modulation Unlocks Stable and Redispersible MXene

open access: yesAdvanced Science, EarlyView.
Amphiphilic lignin‐containing nanocellulose (LNC) establishes competitive interactions between MXene nanosheets, enabling precise modulation of interlayer spacing and interfacial chemistry. This strategy allows rapid fabrication of semi‐solid MXene via industrial‐scale spray drying, achieving long‐term reversible redispersibility and exceptional ...
Shuyang He   +9 more
wiley   +1 more source

Density amplifiers of cooperation for spatial games. [PDF]

open access: yesProc Natl Acad Sci U S A
Svoboda J, Chatterjee K.
europepmc   +1 more source

Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways

open access: yesAdvanced Science, EarlyView.
Decoding sound from neural activity in mice reveals a striking shift in how the brain encodes sound: from precise but redundant timing codes in early auditory areas to efficient, synergistic rate‐based codes in the cortex. This transformation highlights a robust neural strategy for turning complex acoustic input into coherent perception across the ...
Alexa Buck   +7 more
wiley   +1 more source

Carbon Catalyst Supports for Pt‐Based Polymer Electrolyte Membrane Fuel Cells: Porosity, Graphitization, and Chemical Modifications

open access: yesAdvanced Science, EarlyView.
This review explores recent advancements in understanding the influence of carbon support properties on the cathode performance of proton exchange membrane fuel cells. It proposes a set of properties deemed critical for the development of next‐generation carbon supports for the oxygen reduction reaction in fuel cells.
Camille Roiron   +5 more
wiley   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

open access: yesAdvanced Science, EarlyView.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei   +12 more
wiley   +1 more source

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