Results 221 to 230 of about 261,811 (317)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Using the Socio-Technical Allocation of Resources (STAR) approach to support chronic obstructive pulmonary disease management resource allocation in integrated care systems in England. [PDF]
Res Health Serv RegEttinger J +5 more
europepmc +1 more source
Streaming Killed the Download Star! How the Business Model of Streaming Services Revolutionizes Music Distribution [PDF]
, 2015 Timm Trefzger +3 more
openalex
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Inferring three-nucleon couplings from multi-messenger neutron-star observations. [PDF]
Nat CommunSomasundaram R +7 more
europepmc +1 more source
Developing and Evaluating the (LUCID/Star)*Usability Engineering Process Model
, 2001 James W. Helms
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
TCS-FEEL: Topology-Optimized Federated Edge Learning with Client Selection. [PDF]
Sensors (Basel)Chen H, Li H.
europepmc +1 more source