Results 71 to 80 of about 261,811 (317)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Seeding Cores: A Pathway for Nuclear Star Clusters from Bound Star Clusters in the First Billion Years

open access: yesThe Open Journal of Astrophysics
We model the formation of star clusters in a dwarf galaxy progenitor during the first 700 Myr of cosmic history using a cosmological radiation-hydrodynamic simulation with a sub-grid star formation efficiency (SFE) model calibrated from AU-scale ...
Fred Angelo Batan Garcia   +2 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

A detailed self-consistent vertical Milky Way disc model

open access: yesEPJ Web of Conferences, 2012
We present a self-consistent vertical disc model of thin and thick disc in the solar vicinity. The model is optimized to fit the local kinematics of main sequence stars by varying the star formation history and the dynamical heating function.
Gao S., Golubov O., Just A.
doaj   +1 more source

Neutron Star Matter and Neutron Star Models

open access: yesZeitschrift für Naturforschung A, 1974
Various methods to study the ground state of neutron star matter are compared and the corresponding neutron star models are contrasted with each other. In the low density region ρ < 1014gr cm-3 the nuclear gas is treated here by means of a Thomas Fermi method and the nuclei are described by the droplet model of Myers and Swiatecki.
H. Heintzmann   +3 more
openaire   +1 more source

Neutron Star Model Atmospheres [PDF]

open access: yesAIP Conference Proceedings, 2009
Determination of neutron star (NS) parameters is an important astrophysical problem. The stellar radius depends on the mass and the equation of state (EOS) in the NS core, which is not well known. Therefore, with masses and radii inferred from observations we are able to select between various theories for the EOS.
Valery Suleimanov   +8 more
openaire   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Multicomponent Fitting to the Star Formation Histories in the TNG Simulation

open access: yesThe Astrophysical Journal
The star formation history (SFH) is a key issue in the evolution of galaxies. In this work, we developed a model based on a Gaussian and gamma function mixture to fit SFHs with varying numbers of components. Our primary objective was to use this model to
Yang Wang   +5 more
doaj   +1 more source

Finite-Horizon Robust Kalman Filter for Uncertain Attitude Estimation System with Star Sensor Measurement Delays

open access: yesAbstract and Applied Analysis, 2014
This paper addresses the robust Kalman filtering problem for uncertain attitude estimation system with star sensor measurement delays. Combined with the misalignment errors and scale factor errors of gyros in the process model and the misalignment errors
Hua-Ming Qian, Wei Huang, Biao Liu
doaj   +1 more source

Home - About - Disclaimer - Privacy