Results 51 to 60 of about 19,545 (258)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Современные информационные технологии и IT-образование, 2018 The Dynamic nature of modern business operations, the constant growth and the complexity of the data flows companies to turn to the most advanced data processing means, one of these tools is the Business Intelligence (BI) tool: offering a range of ...
Lyes Mekid
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Complexity, 2018 The heterogeneous information networks are omnipresent in real-world applications, which consist of multiple types of objects with various rich semantic meaningful links among them.
Jibing Wu +6 more
doaj +1 more source
A big data analytics platform to support simulation modeling for osteoarthritis care pathways
International Journal of Population Data Science, 2018 Introduction Technical solutions have been used in industry settings for many years to facilitate efficient management and analyses of big data sources.
Shelly Vik +3 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Research of university data statistical platform based on data warehouse
Tongxin xuebao, 2013 In order to adapt to the demand of statisting and analyzing huge-data in universities under current situation,an overall programme was designed and implemented to construct data statistical service platform based on data warehouse.The overall framework ...
Xin-zheng LONG +5 more
doaj +2 more sources
A clustering approach for detecting implausible observation values in electronic health records data
BMC Medical Informatics and Decision Making, 2019 Background Identifying implausible clinical observations (e.g., laboratory test and vital sign values) in Electronic Health Record (EHR) data using rule-based procedures is challenging.
Hossein Estiri +2 more
doaj +1 more source
Pattern Mining over Star Schemas in the Onto4AR Framework [PDF]
2009 IEEE International Conference on Data Mining Workshops, 2009 Storing data according to the multidimensional model, in particular following star schemas, has demonstrated to be one of the most adequate forms to ease the exploration of data. However, this exploration has been limited to be query-based, leaving the discovery of hidden information to a second plan.
openaire +1 more source