Results 61 to 70 of about 19,545 (258)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
A Review of Star Schema Benchmark
, 2016 This paper examines the Star Schema Benchmark, an alternative to the flawed TPC-H decision support system and presents reasons why this benchmark should be adopted over the industry standard for decision support systems.
openaire +2 more sources
BUSINESS INTELLIGENCE DEVELOPMENT MODEL USING STAR SCHEMA METHODOLOGY
CCIT Journal, 2012 Nowdays, implemented the information systems that are integrated to business processes in the organization has become a primary necessity. Information systems in the organization are mostly used to assist the implementation of enterprise business process.
Meta Amalia Dewi +2 more
openaire +2 more sources
Dimensional Modeling Using Star Schema for Data Warehouse Creation [PDF]
Oriental journal of computer science and technology, 2017 Data Warehouse design requires a radical rebuilding of tremendous measures of information, frequently of questionable or conflicting quality, drawn from various heterogeneous sources. Data Warehouse configuration assimilates business learning and innovation know-how.
openaire +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
KARAR DESTEK SİSTEMLERİNİN KULLANIMI İÇİN UYGUN BİR MODEL GELİŞTİRİLMESİ
Havacılık ve Uzay Teknolojileri Dergisi, 2010 In this study by reconstruction of the data sets that the decision maker has already has; a user friendly decision support system is designed by which the users can easily get first-rate reports that support their decision making. The data sets which are
Volkan Aslan, Güray Yılmaz
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Psychos Are Coming, the Psychos Are Coming … They’re Already Here
Voices in Bioethics, 2016 American director Steven Soderbergh’s Contagion wastes no time in laying out the context of his film on the contemporary interconnectedness of the earth’s inhabitants and the concomitant susceptibility to catastrophe that such relationships imply ...
Edmund Weisberg
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source