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Targeting TrkB-PSD-95 coupling to mitigate neurological disorders. [PDF]
Neural Regen ResYang X, Yang X, Huang YA, Marshall J.
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Classification of Current Experimental Models of Epilepsy. [PDF]
Brain SciRubio C +3 more
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Fusion pore flux controls the rise-times of quantal synaptic responses. [PDF]
J Gen PhysiolJackson MB, Chiang CW, Cheng J.
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Stargazin and the AMPA receptor
Science, 2016Structural Biology AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking, gating, and pharmacology.
S. Hurtley
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Stargazin differentially modulates ampakine gating kinetics and pharmacology
Biochemical Pharmacology, 2018It was previously reported that Stargazin (STG) enhances the surface expression of AMPA receptors, controls receptor gating and slows channel desensitization as an auxiliary subunit of the receptors. Ampakines are a class of AMPA receptor positive allosteric modulators that modify rates of transmitter binding, channel activity and desensitization ...
D. Radin +4 more
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Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Nature, 2000Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate) receptors on cerebellar granule cells. Stargazin, the mutated protein, interacts with both AMPA receptor subunits and synaptic PDZ proteins, such as PSD-95.
Lu Chen +7 more
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Stargazin modulates AMPA receptor gating and trafficking by distinct domains
Nature, 2005AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors mediate fast excitatory synaptic transmission in the brain. These ion channels rapidly deactivate and desensitize, which determine the time course of synaptic transmission. Here, we find that the AMPA receptor interacting protein, stargazin, not only mediates AMPA receptor ...
S. Tomita +7 more
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Inhibition of AMPA Receptors by Polyamine Toxins is Regulated by Agonist Efficacy and Stargazin
Neurochemical Research, 2014The α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are glutamate-gated cation channels mediating the majority of fast excitatory synaptic transmission in the central nervous system (CNS). Polyamine toxins derived from spiders and wasps are use- and voltage-dependent channel blockers of Ca(2+)-permeable AMPARs.
M. H. Poulsen +3 more
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Stargazin modulates AMPA receptor antagonism
Neuropharmacology, 2008AMPA receptors mediate the majority of fast synaptic transmission and underlie several forms of synaptic plasticity. AMPARs also have an important role in several neuronal pathologies. Therefore, studying the structure and function of these receptors is important for understanding general mechanisms of synaptic transmission as well as for the ...
Valentin Stein, Barbara Cokic
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Stargazin involvement with bipolar disorder and response to lithium treatment
Pharmacogenetics and Genomics, 2008Multiple reports have implicated chromosomal region 22q13.1 in both schizophrenia and bipolar disorder. The calcium channel gamma-2 subunit gene (cacng2, Stargazin) located on 22q13.1 was recently reported to be associated with schizophrenia. We aimed to examine the expression levels of Stargazin in post-mortem brain samples of patients with ...
Silberberg, G +9 more
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