Results 191 to 200 of about 2,979 (206)

Learning from stargazin: the mouse, the phenotype and the unexpected

Current Opinion in Neurobiology, 2006
The stargazin gene (also referred to as Cacng2) has been identified by forward genetics in a spontaneous mouse mutant with ataxic gait, upward head-elevating movements (hence the name stargazer for the mouse) and episodes of spike-wave discharges. Stargazin is related to the gamma-1 subunit of skeletal muscle voltage-dependent calcium channel (VDCC ...
Osten, P., Stern-Bach, Y.
openaire   +4 more sources

Differential localization and regulation of stargazin-like protein, γ-8 and stargazin in the plasma membrane of hippocampal and cortical neurons

Neuroscience Research, 2006
Transmembrane AMPA receptor regulatory proteins (TARPs), including stargazin/gamma-2, are associated with AMPA receptors and participate in their surface delivery and anchoring at the postsynaptic membrane. TARPs may also act as a positive modulator of the AMPA receptor ion channel function; however, little is known about other TARP members except for ...
Sumio Hoka, Saori Yamamori, Makoto Itakura, Ryuichi Shigemoto, Akira Mizoguchi, Mihoko Inamura, Hirotsugu Okamoto, Yugo Fukazawa, Masami Takahashi   +8 more
openaire   +3 more sources

Stargazin interacts functionally with the AMPA receptor glutamate-binding module

Neuropharmacology, 2007
Neuronal AMPA receptors comprise pore forming glutamate receptor (GluR) proteins and auxiliary transmembrane AMPA receptor regulatory (TARP) subunits. TARPs traffic AMPA receptors to synapses and regulate channel gating. Both intracellular and extracellular regions in TARPs regulate AMPA receptors; however, the details for these interactions remain ...
Yuko Fukata, Susumu Tomita, Archana Shenoy, David S. Bredt, Roger A. Nicoll   +4 more
openaire   +3 more sources

Dynamic Interaction of Stargazin-like TARPs with Cycling AMPA Receptors at Synapses [PDF]

Science, 2004
Activity-dependent plasticity in the brain arises in part from changes in the number of synaptic AMPA receptors. Synaptic trafficking of AMPA receptors is controlled by stargazin and homologous transmembrane AMPA receptor regulatory proteins (TARPs). We found that TARPs were stable at the plasma membrane, whereas AMPA receptors were internalized in a ...
Masaki Fukata, David S. Bredt, Susumu Tomita, Roger A. Nicoll   +3 more
openaire   +2 more sources

A novel action of stargazin as an enhancer of AMPA receptor activity

Neuroscience Research, 2004
Stargazin (gamma-2) is disrupted in the ataxic and epileptic mutant mouse, stargazer (stg). The striking defect in the stg cerebellum is the lack of functional AMPA receptors on granule cells. Recently, it has been reported that gamma-2 and its related molecules are crucial for the surface expression, synaptic targeting and recycling of AMPA receptors,
Maya Yamazaki, Takako Ohno-Shosaku, Masahiro Fukaya, Masanobu Kano, Kenji Sakimura, Masahiko Watanabe   +5 more
openaire   +3 more sources

c-Fos, Arc, and Stargazin expression in rat eyeblink conditioning.

Behavioral Neuroscience, 2011
Neuronal plasticity induced by behavioral experience, as in memory formation, has been considered to involve transcriptional or translational changes in subsets of neurons involved in different forms of learning. Here, alteration in protein expression during cerebellar learning was investigated using rat eyeblink conditioning.
Richard F. Thompson, Soyun Kim
openaire   +2 more sources

Additive regulation of GluR1 by stargazin and serum- and glucocorticoid-inducible kinase isoform SGK3

Pflügers Archiv - European Journal of Physiology, 2006
The serum- and glucocorticoid-inducible kinase isoform 3 (SGK3) and stargazin have both been shown to enhance the synaptic expression level of GluR1. The present study was performed to elucidate whether SGK3 and stargazin interact or are effective through different pathways in the regulation of GluR1.
Ravshan Baltaev, Guiscard Seebohm, Ganna Korniychuk, Florian Lang, Oana N. Ureche, Marion Striegel, Nathalie Strutz-Seebohm   +6 more
openaire   +3 more sources

Stargazin Transports AMPA Receptors

Science Signaling, 2001
The murine stargazer phenotype is manifested by ataxia and epileptic seizures and is caused by mutations in the stargazin protein. Chen et al . describe the role of stargazin in the proper localization of AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole propionate) receptors but not NMDA ( N ...
openaire   +2 more sources

Crystal structure of the human Arc N-lobe bound to stargazin

, 2020
E. Hallin, C. Bramham, P. Kursula
semanticscholar   +1 more source

Faculty Opinions recommendation of A role for stargazin in experience-dependent plasticity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2019
M. Kano, Takaki Watanabe
semanticscholar   +1 more source