Results 11 to 20 of about 43,147 (179)

Multiple biliary duct hamartomas in a cat resulting in a hepatic mass: A case report. [PDF]

Vet Med Sci, 2023
A 13‐year‐old, male neutered domestic short‐haired cat was diagnosed with multiple biliary duct hamartomas after liver lobectomy for a suspected malignant hepatic mass. Prior to surgery, comparative diagnostic imaging, including abdominal ultrasound and computed tomography of the abdomen both identified a lobular, well‐defined left hepatic mass ...
Naghi R, Bertran J, Spoldi E, Dark MJ, de Oliveira HH, Souza C, Maxwell EA.   +6 more
europepmc   +2 more sources

Liver-Directed Gene Therapy Mitigates Early Nephropathy in Murine Glycogen Storage Disease Type Ia. [PDF]

J Inherit Metab Dis
ABSTRACT Nephropathy is a complication of glycogen storage disease type Ia (GSD‐Ia), a metabolic disorder caused by pathogenic variants in glucose‐6‐phosphatase‐α (G6Pase‐α or G6PC1). While maintaining blood glucose homeostasis can delay the progression of renal disease in GSD‐Ia, the benefits of liver‐directed G6PC1 gene therapy on nephropathy remain ...
Lee C, Pratap K, Zhang L, Chen HD, Arnaoutova I, Starost MF, Mansfield BC, Chou JY.   +7 more
europepmc   +2 more sources

Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response

Glia, Volume 71, Issue 9, Page 2180-2195, September 2023., 2023
Main Point We observe a more rapid and robust remyelination response in the presence of an inflammatory environment with the combined treatment of Sephin1 and BZA as a result of different mechanisms of action of the drugs on the remyelinating oligodendrocyte lineage cells.
Yanan Chen, Songhua Quan, Vaibhav Patil, Rejani B. Kunjamma, Haley M. Tokars, Eric D. Leisten, Godwin Joy, Samantha Wills, Jonah R. Chan, Yvette C. Wong, Brian Popko   +10 more
wiley   +1 more source

Influx of T cells into corpus callosum increases axonal injury, but does not change the course of remyelination in toxic demyelination

Glia, Volume 71, Issue 4, Page 991-1001, April 2023., 2023
Main Points Induction of the adaptive immune system increases T cell numbers and axonal injury, but does not affect the course of remyelination. Our data suggest that oligodendrocytes are less susceptible to T cell mediated injury than axons. Abstract Multiple sclerosis (MS) is a focal inflammatory and demyelinating disease.
Elif Nur Yilmaz, Stefanie Albrecht, Katharina Groll, Christian Thomas, Lutz Wallhorn, Martin Herold, Stephanie Hucke, Luisa Klotz, Tanja Kuhlmann   +8 more
wiley   +1 more source

Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice

Aging Cell, Volume 21, Issue 2, February 2022., 2022
Here, we demonstrate that mild mitochondrial uncoupling via CRMP treatment reduces hepatic steatosis and improves hepatic insulin sensitivity in aged HFD‐fed mice. Long‐term CRMP treatment protects aged HFD‐fed mice against hepatocellular carcinoma in a strain and sex‐specific manner.
Leigh Goedeke, Kelsey N. Murt, Andrea Di Francesco, João Paulo Camporez, Ali R. Nasiri, Yongliang Wang, Xian‐Man Zhang, Gary W. Cline, Rafael de Cabo, Gerald I. Shulman   +9 more
wiley   +1 more source

Stem cell derived oligodendrocytes to study myelin diseases

Glia, Volume 68, Issue 4, Page 705-720, April 2020., 2020
Main Points Oligodendrocytes are functionally involved in many CNS diseases. iPSC derived oligodendrocytes represent a promising tool for disease modeling, compound screenings, and potentially cell replacement therapies. Abstract Oligodendroglial pathology is central to de‐ and dysmyelinating, but also contributes to neurodegenerative and psychiatric ...
Konstantina Chanoumidou, Sabah Mozafari, Anne Baron‐Van Evercooren, Tanja Kuhlmann   +3 more
wiley   +1 more source

Nove interpretacije fluvialnih sedimentov na Krasu

Dela, 2007
Predstavljene so pomembne brezstrope jame s fluvialnimi sedimenti na Divaškem krasu, v Matarskem podolju in Podgorskem krasu. Opisana je njihova prostorska razprostranjenost ter odnos do obstoječih jam in kraškega površja ter njihov geomorfološki pomen ...
Andrej Mihevc
doaj   +1 more source

Starost i depresija [PDF]

Depression in the Century of Mind, 4th Croatian Congress in Prevention and Rehabilitation in Psychiatry, 2015
The aim of the study was to examine the incidence and level of depression among people over 65 years of age in Osijek-Baranja County. The aim was to specifically examine the incidence of depression in older people, with regard to gender, age, education, marital status, parenthood, type of housing (own home, home for the elderly and disabled), reasons ...
B. Kandić-Splavski, D. Sladić Rimac, S. Kanisek, I. Barać   +3 more
openaire   +2 more sources

Environmental Particle Emissions due to Automated Drilling of Polypropylene Composites and Nanocomposites Reinforced with Talc, Montmorillonite and Wollastonite [PDF]

, 2017
In this study, the effect on nanoparticle emissions due to drilling on Polypropylene (PP) reinforced with 20% talc, 5% montmorillonite (MMT) and 5% Wollastonite (WO) is investigated.
A Egizabal, Bello D, C Elizextea, E Frijns, I Nelissen, ISO B. 527-2, J Njuguna, J V Laer, K Starost, M Blazquez, N Faisal, Njuguna J, Starost K, Starost K   +13 more
core   +2 more sources

Napovedni pomen odnosa med vrednotami, depresijo, komorbiditeto in percepcijo kakovosti življenja starih rehabilitandov

Psihološka Obzorja, 2002
Cilj raziskave je bil proučiti napovedni pomen odnosa med vrednotami, depresijo, komorbiditeto in percepcijo kakovosti življenja 80 rehabilitandov, starejših od 65 let in s poprečno starostjo 74,4.
Tone Brejc
doaj   +1 more source