Results 121 to 130 of about 59,534 (217)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Modified sports intervention for improving participation goals and activity competence in ambulant children with cerebral palsy: A randomized controlled trial. [PDF]

Dev Med Child Neurol
Sousa Junior RR, Clutterbuck GL, Guimaraes RF, Souza MG, Silva LC, Wright FV, Camargos ACR, Leite HR.   +7 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Association between anaemia and osteoporosis: a systematic review and meta-analysis. [PDF]

Ann Med
Tear AA, Tesno FA, Shofiadeita H, Bunga GM, Taqiya HN, Sanditha NA, Fayyaza AH, Tambunan SKT, Wangsa GK, Fatimah QR, Istiqomah I, Wibawanty W, Lubis L.   +12 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Optimal duration of perioperative antibiotics in radical cystectomy and urinary diversion: a systematic review and meta-analysis. [PDF]

Langenbecks Arch Surg
Mohamed T, Bani Irshid BA, Elhashamy H, Deameh MG, Hassab El-Naby A, Ramez M.   +5 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Patient- and Clinician-Reported Outcomes and the Outcome Measures in Studies Reporting on Rehabilitation of the Edentulous Maxilla With Implant-Supported Fixed Prosthesis Using Short, Standard-Length and/or Zygomatic Implants: A Systematic Review of Clinical Studies Published in the Last 10 Years. [PDF]

Clin Oral Implants Res
Thoma DS, Sadilina S, Jung RE, Park SH, Park JY, Jung UW, Strauss FJ.   +6 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Impact of spring sea ice variability in the Barents-Kara region on the Indian Summer Monsoon Rainfall. [PDF]

Sci Rep
Sardana D, Agarwal A.
europepmc   +1 more source