Results 91 to 100 of about 85,147 (265)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Investigating the A-Type Stars Using Kepler Data

, 2013
Rotation is a key physical process operating in the A stars. We present a method by which rotation periods might be measured with Fourier transforms of Kepler data, potentially removing the requirement of spectroscopic observations to acquire similar ...
Murphy, Simon J.
core  

Spectrophotometry of early type stars [PDF]

, 2020
A photoelectric spectrum scanner attached to the 16-inch telescope of the Cerro Tololo Inter-American Observatory was used to determine the relative spectral intensity distribution for early type stars.
Stock, J, Moreno, H., Gutiérrez-Moreno, A.   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The evolution of magnetic fields in early B-type stars

, 2009
To date, only a small number of O and early B-type stars have been investigated for magnetic fields, and as a result, only about a dozen magnetic early B-type stars and only few magnetic O stars are known. The lack of information on the existence, origin
Morel, Thierry, Briquet, Maryline, Scholler, M., Hubrig, S., De Cat, P.   +4 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Differential rotation in early type stars

, 2006
Using 2D models of rotating stars, the interferometric measurements of alpha Eri and its fundamental parameters corrected for gravitational darkening effects we infer that the star might have a core rotating 2.7 times faster than the surface. We explore the consequences on spectral lines produced by surface differential rotation combined with the ...
Zorec, J., Frémat, Y., Domiciano de Souza, A.   +2 more
openaire   +3 more sources

Photometric variability of some early-type stars

, 1986
peer reviewedPhotometric observations of 12 variable early type stars are presented. The properties of individual stars are discussed, and an attempt is made to interpret their variability.
Mathys, G., Manfroid, Jean, Renson, Pierre   +2 more
core