Results 41 to 50 of about 43,527 (197)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Intrinsic dispersion in early-type stars [PDF]
Symposium - International Astronomical Union, 1959 The principal basic parameters of early-type stars being mass and age, two-dimensional classification according to the MK system corresponds to a mass-age classification.
openaire +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Spectrophotometry of early type stars
, 1969 A photoelectric spectrum scanner attached to the 16-inch telescope of the Cerro Tololo Inter-American Observatory was used to determine the relative spectral intensity distribution for early type stars. Observations on a minimun of three nights per star have been obtained for about two hundred stars. The tracings extend from 3100 Å to 6000 Å. They were
Gutiérrez-Moreno, A. +2 more
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The Theory of Winds in Early Type Stars [PDF]
International Astronomical Union Colloquium, 1981 I assume that the purpose of this review of the theory of winds from early type stars is to summarize the way in which the mass loss rate of a star may be included in a calculation of stellar evolution. Let me summarize my conclusions. It is not possible. One can only use estimates of mass loss rates obtained from the observations.
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Observations of Stellar Winds in Early Type Stars [PDF]
International Astronomical Union Colloquium, 1981 I have been asked to review the “observations” of winds in “early-type” stars. This normally means stars of spectral type OB and those of the Wolf-Rayet (WR) class. In this paper I will concentrate on the massive population I stars of these types, and primarily the O and WR classes on which most of the recent work has been done.
openaire +1 more source